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NSH
Join NSH for five days of great VIR education. Topics for this year’s series are: Antibody Production: Polyclonals, Monoclonals, and New Developments; Simple Tools for 3-Dimensional Image Processing; Multiplexing on Animal and Xenograft Tissue, All Things Considered; Superresolution Expansion Microscopy; Developing Immunohistochemical (IHC) Assays for Animal Models of Disease. Individual or lab purchasing options are available. Click here to learn more and to register.
NSH
Not currently an NSH member? When you join NSH today, not only are you receiving membership for 2018, but you are also getting the rest of 2017, at no cost. That means almost additional months of access to key resources you could benefit from, such as all of the tools available on NSH’s member community, The Block, as well as discounts on upcoming webinars, such as the VIR series launching this month, all at no additional cost to you! Don’t miss out on two free months of benefits! Join Today!
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Healio
Visceral adipose tissue mass does not increase linearly with adiposity, and the threshold where accumulation affected insulin sensitivity and cardiovascular risk differs by gender, according to research presented at Obesity Week 2014. “There appears to be a threshold that occurs wherein visceral fat begins to accumulate more in the visceral region than it does in the subcutaneous regions around the body, which suggests the subcutaneous fat can’t store anymore, so it shifts it ectopically,” Tyler Bosch, Ph.D., a post-doctoral fellow at the University of Minnesota Medical School, told Endocrine Today.
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The JAMA Network
Ehlers-Danlos syndromes are a group of heritable connective tissue disorders. Patients with EDSs can develop excessive facial rhytids, nasal deformities, and facial scarring, for which they may seek consultation with a facial plastic surgeon. Ehlers-Danlos syndromes can be associated with serious surgical complications and should be identified preoperatively to facilitate optimal treatment. To our knowledge, no management guidelines for patients with EDSs exist in the facial plastic surgery literature. We present a review of the literature and management recommendations for the facial plastic surgeon.
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Genetic Engineering & Biotechnology News
Chemotherapy could be more effective if it were combined with the inhibition of a newly discovered form of DNA repair, a mechanism that cells activate to fix exactly the sort of damage that many chemotherapy drugs cause—or are supposed to cause. The relevant chemotherapy drugs are alkylating agents, which try to kill cancer cells by adding alkyl groups to DNA. These debilitating accretions, however, can be removed by an alkylation repair complex.
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Cancer Network via Modern Medicine
Achievement of event-free survival at 24 months is highly predictive of overall survival in patients with peripheral T-cell lymphomas, according to a new study.
PTCLs are a group of non-Hodgkin lymphomas with a generally aggressive clinical presentation. Previous research showed that EFS can be useful in stratifying patients with other lymphomas including diffuse large B-cell lymphoma and follicular lymphoma treated with immunochemotherapy, and researchers led by Andrew L. Feldman, M.D., of the Mayo Clinic in Rochester, Minnesota, aimed to assess its use in PTCL as well.
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University of Illinois at Urbana-Champaign via Medical Xpress
Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to amputation.
A new study in mice at the University of Illinois found that an injection of the stem cells prompted new blood vessels to grow, improving circulation in the affected tissues and function in the affected limbs. The stem cells also induced changes in gene expression in the surrounding tissues, prompting the release of factors to reduce inflammation and increase circulation. The study was published in the journal Theranostics.
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Aquaro ASM automates section mounting to provide consistent, high quality slides, increased lab efficiency, and improved work life in the lab.
Learn more by downloading the whitepaper or viewing a video about the ASM. MORE
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The Medical News
A surprise finding suggests that an injection of nanoparticles may be able to help fight the immune system when it goes haywire, researchers at the University of Michigan have shown. The nanoparticles divert immune cells that cause inflammation away from an injury site.
Inflammation is a double-edged sword. When it works, it helps the body heal and fights off infections. But sometimes, the immune system overreacts. An acute lung injury, sustained by inhaling smoke, for instance, can lead to runaway fluid production that essentially drowns a person.
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German Cancer Research Center via Medical Xpress
An enzyme that is responsible for the breakdown of specific amino acids in food plays a key role in the development of leukemias and brain cancer, according to scientists from the German Cancer Research Center in Heidelberg. They have reported their findings in Nature. The researchers have discovered a surprising link between energy metabolism and the so-called epigenetic code. These labels in the DNA of cancer stem cells determine the activity of genes, and thus, many cellular functions. The authors think that blocking this enzyme is a promising approach to combat cancer.
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PRODUCT SHOWCASE
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GBI Labs produces the largest selection of secondary detection kits, from single to multiple detection kits, with wide range host species.
We provide FREE samples to 1st time users. Staining with our kits results in similar or better sensitivity than other detection kits on the market with 20%-30% cost less.
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The Medical News
A newly developed tool to analyze the cellular and molecular profiles of synovial tissue and peripheral blood may help unlock clues about rheumatoid arthritis and lead to better therapies, according to new research findings presented recently at the 2017 ACR/ARHP Annual Meeting in San Diego.
Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling, and limitation in the motion and function of multiple joints. Though joints are the principal body parts affected by RA, inflammation can develop in other organs as well. An estimated 1.3 million Americans have RA, and the disease typically affects women twice as often as men.
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The JAMA Network
Accumulating evidence indicates that tumor-infiltrating lymphocytes are associated with clinical outcomes and may predict the efficacy of chemotherapy and human epidermal growth factor receptor 2 targeted therapy in patients with HER2-positive breast cancer. To investigate the role of TILs, particularly cytotoxic CD8+ T cells, in the prediction of outcomes in patients with HER2-positive metastatic breast cancer randomized to an antibody-based vs a small molecule–based anti-HER2 therapy.
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Primera’s Signature Slide and Cassette Printers can significantly increase the efficiency of your lab while helping to reduce the risk of misidentification of specimens. MORE
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Kyoto University via ScienceDaily
Researchers have made biodegradable aligned nanofibers as a scaffold for culturing cardiomyocytes derived from human induced pluripotent stem cells. Researchers obtained high-quality cardiac tissue-like constructs by cultivating hiPSC-CMs on aligned nanofibers made of biodegradable polymer. Researchers show that multi-layered and elongated CMs could promptly be organized at high density along aligned nanofibers, resulting in upregulated cardiac biomarkers and enhanced cardiac functions.
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Missed last week's issue? See which articles your colleagues read most.
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Under the Microscope
Connect with NSH
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Colby Horton, Vice President of Publishing, 469-420-2601 | Download media kit
Ashley Harrington, Senior Content Editor, 469-420-2642 | Contribute news
The NSH membership community is made of individuals actively engaged in all aspects of the histology field, as well as others with past or future interest in histology, such as students and retired professionals. Together, we are more than 3,000 members strong and growing, working as an organization to strengthen the histology profession through quality education and professional relationships to enrich and grow careers. To find out more on how to join NSH, click here.
National Society for Histotechnology
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