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Happy Thanksgiving from NSH
NSH
The National Society for Histotechnology wishes everyone a Happy Thanksgiving. Wishing this holiday finds you and your family with plenty of reasons to give thanks. We want to thank all of our members and supporters, thank you for all that you do for our organization.
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Team finds potential cause for deadly breast cancer relapse
Medical Xpress
Researchers at the University of North Carolina School of Medicine, working with cell lines in a lab, have discovered why some of the most aggressive and fatal breast cancer cells are resistant to chemotherapy, and UNC scientists are developing ways to overcome such resistance. Adriana S. Beltran, Ph.D., a research assistant professor in the department of pharmacology, found that the protein Engrailed 1 is overexpressed in basal-like carcinomas and designed a chain of amino acids to shut down the protein and kill basal-like tumors in the lab.
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Scientists develop laser-powered compact X-ray device
R&D Magazine
Using a compact but powerful laser, a research team at the University of Nebraska-Lincoln has developed a new way to generate synchrotron X-rays.
Although the high quality of synchrotron X-rays make them ideal for research ranging from the structure of matter to advanced medical images, access to the technology has been limited until now. Most traditional synchrotron X-ray devices are gigantic and costly, available only at a few sites around the world.
Research targets parasitic worm disease
Iowa State University via Medical Xpress
The worms can live inside your body for years, decades even. And it's not the worms themselves that will eventually make you sick. Rather, it's the thousands of eggs they lay.Schistosomes, small parasitic flatworms that have infected hundreds of millions of people in developing nations, cause chronic illness that damages organs and impairs development in children.
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Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE
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Biologists ID new cancer weakness
MIT News
About half of all cancer patients have a mutation in a gene called p53, which allows tumors to survive and continue growing even after chemotherapy severely damages their DNA. A new study from MIT biologists has found that tumor cells with mutated p53 can be made much more vulnerable to chemotherapy by blocking another gene called MK2. In a study of mice, tumors lacking both p53 and MK2 shrank dramatically when treated with the drug cisplatin, while tumors with functional MK2 kept growing after treatment.
Marker predicts radiation failure in nasopharyngeal cancer
Medscape
A cytokine found in the blood of patients with nasopharyngeal carcinoma can lead to a strategy for sensitizing some radiotherapy-resistant tumors, according to a study published online Nov. 25 in the Journal of Clinical Investigation. Shu-Chen Liu, Ph.D., associate professor at the Molecular Medicine Research Center at Chang Gung University, Taoyuan, Taiwan, and colleagues found increased serum levels of leukemia inhibitory factor in patients with local tumor recurrence after radiotherapy for Epstein-Barr virus-associated NPC.
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Visit LabStorage System’s updated website to view details about this new laboratory seating with specially formulated Infection Control coating. Non-porous and easily disinfected, this moisture proof coating is anti-bacterial, anti-fungal and stain resistant. more
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Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
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Growth factors for cell culture
Genetic Engineering & Biotechnology News
The focus of this GEN Market & Tech Analysis Report is to present the market segmentation and quantitative landscape for growth factors as they are currently utilized for cell culture in various application spaces. We've characterized the marketplace based on telephone interviews as surveys of researchers around the world, and based on this bottom-up analysis we've identified the top growth factors that are currently utilized in the research environment.
Novel oral anticoagulants for thromboembolic disease
By Dr. Afsaneh Motamed-Khorasani
 Vitamin K antagonists are commonly used for the treatment of thromboembolic disease. However, the slow onset of action for these medications limits their use. Therefore, a bridging therapy with the use of low molecular weight heparin, or LMWH is advantageous for the treatment. LMWH has a reduced rate of adverse effects and has replaced the use of heparin. Since heparin and LMWH are parenteral drugs, continuous attempts have been made for alternative oral drugs, and many oral anticoagulants are in phase 3 clinical trials.
Chemotherapy: When intestinal bacteria provide reinforcement
Science Codex
Researchers have just shown that the efficacy of one of the molecules most often used in chemotherapy relies to an extent on its capacity to mobilize certain bacteria from the intestinal flora toward the bloodstream and lymph nodes. Once inside the lymph nodes, these bacteria stimulate fresh immune defenses, which then enhance the body's ability to fight the malignant tumor. Results of this work were published in the journal Science on Nov. 22.
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