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 Top Stories

Converging technologies enable faster diagnoses by pathologists and physicians
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Innovative and inexpensive technologies hold the promise of instantaneous diagnosis while transforming conventional clinical laboratory tools "point-of-care pathology" may not be that far away. The convergence of medical and information technologies, the falling cost of computing, and the growing availability of miniaturization technologies make it increasingly possible for pathologists and physicians to make informed, on-the-spot diagnostic decisions about patient care. A new wave of imaging technologies — including pathology tools — is poised to transform the practice of medicine, reported a recent story in The New York Times. More

Introducing New RabMAbs for Lymphoma
Introducing new rabbit monoclonal antibodies (RabMAbs®) from Epitomics. Epitomics now has over 170 EP Clones, available in 16 Disease Panels including Lymphoma markers to the following antibodies: CD4, CD10, IgD, MUM1. For more information about these antibodies and the advantages of Rabbit Monoclonal antibodies, click here.


Fungus has cancer-fighting power
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Arthrobotrys oligospora doesn't live a charmed life; it survives on a diet of roundworm. But a discovery by a team led by Mingjun Zhang, an associate professor of biomedical engineering at the University of Tennessee, Knoxville, could give the fungus's life more purpose — as a cancer fighter. Zhang and his team have discovered that nanoparticles produced by A. oligospora hold promise for stimulating the immune system and killing tumors. More

Innovative stem cell technique for heart tissue revealed
medwireNews via The Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have found that stem cell cultures infused with growth factors could be used to repair damaged heart tissue without the threat of patient rejection. Ren-Ke Li and team say that their discovery transforms aged stem cells into cells that function like much younger ones. These may one day enable scientists to grow cardiac patches for diseased or damaged hearts from a patient's own stem cells, no matter how old they are, while avoiding the risk for rejection. More

Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE


Clinical trial targets advanced prostate cancer
Georgia Health Sciences University via Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Select patients with advanced prostate cancer may benefit from a Georgia Health Sciences University Cancer Center clinical trial that looks to improve survival rates of the FDA-approved prostate cancer drug Provenge. The trial, led by GHSU Cancer Center Director Samir N. Khleif, is the first in the country to investigate prostate cancer treatment combining Provenge with two other cancer-fighting drugs, CT-011 and cyclophosphamide. As the first FDA-approved immunotherapy treatment for prostate cancer, Provenge has been found to extend life expectancy of certain men with advanced prostate cancer by nearly 20 percent. More

World's smallest wrench controls tiny particles
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Harnessing laser light's ability to gently push and pull microscopic particles, researchers have created the fiber-optic equivalent of the world's smallest wrench. This virtual tool can precisely twist and turn the tiniest of particles, from living cells and DNA to microscopic motors and dynamos used in biological and physical research. This new twist on controlling the incredibly small, developed by physicists at The University of Texas at Arlington, will give scientists the ability to skillfully manipulate single cells for cancer research, twist and untwist individual strands of DNA, and perform many other functions where microscopic precision is essential. More




 NSH News


2013 NSH teleconference/webinar series
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
NSH teleconferences (now available as webinars) are a great, inexpensive way to provide continuing education to a large number of employees. The cost for each session is the same regardless of the number of attendees. The one-hour session is usually held the fourth Wednesday of the month, beginning at 1 p.m. EST. Occasionally, due to holidays, it may be the third Wednesday of the month. More


DIGITAL HOLOGRAPHY FOR CELL STUDY

NanoAndMore USA provides DHMs from Lyncée tec and Resolution Optics. They sense the change in the liquid content of cells and image in 3D.
MORE
Sensitive and specific 2-plex RNA-ISH assay

Affymetrix’ QuantiGene® ViewRNA Assays enable single-copy RNA sensitivity with exceptional specificity in FFPE tissue sections. From sequence to assay in 1 week. View recent publications.



 In the News


Supreme Court to decide whether isolated genes can be patented
ABA Journal    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The U.S. Supreme Court agreed to decide whether isolated genes can be patented. The court granted cert in a case challenging patents on genes associated with increased risk of breast and ovarian cancer, report The New York Times, Bloomberg News and SCOTUSblog. At issue is whether isolated genes are "human-made inventions" that can be patented, or "products of nature" that may not be patented, the Times explains. More



Scientists develop faster, safer method for producing stem cells
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new method for generating stem cells from mature cells promises to boost stem cell production in the laboratory, helping to remove a barrier to regenerative medicine therapies that would replace damaged or unhealthy body tissues. The technique, developed by researchers at the Salk Institute for Biological Studies, allows for the unlimited production of stem cells and their derivatives as well as reduces production time by more than half, from nearly two months to two weeks. More

New Alzheimer's drug clinical trial offers hope amid frustrations
Everyday Health    Share    Share on FacebookTwitterShare on LinkedinE-mail article
VideoBriefThe pharmaceutical company Merck has started a phase two and phase three clinical trial to evaluate a new oral medicine aimed at slowing or stopping the progression of Alzheimer's disease. The trial represents hope for Alzheimer's patients and their families, who have endured years of scientific stumbles, failed experimental drugs and little progress toward clinical therapies to treat Alzheimer's disease. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Slimsette™ Recessed Cover Tissue Cassettes
Available in slotted, biopsy and four compartment versions, the Slimsette™ recessed cover allows for use with lids attached during labeling in cassette printers. Part of the full line of cassettes from LabStorage Systems, Slimsette™ comes in convenient dispenser boxes or preloaded in plastic sleeves for automatic printers. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Optimal feed strategies to enhance protein production of CHO clones using thermo scientific HyCell CHO and cell boost feeds
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Process development and optimization is critical to enhancing the productivity of various cell lines. Nutrient requirements for peak productivity can be clone and process specific. Implementing the right feed formulation and strategy can greatly enhance the productivity of cell cultures in a fed-batch process. A small-scale design of experiment method was used to determine the optimal feed strategy (formulation, concentration and timing) to maximize both product titer and peak viable cell density for several CHO clones. More

Nobel awarded to 2 stem cell researchers
GreenAnswers    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The field of stem cell research, while often controversial, has received a major boost recently as two researchers were awarded with the Nobel in physiology or medicine for their work. Their work, although separated by more than 40 years, is seen as a breakthrough in the understanding of cell biology and development. News that John B. Gurdon of England's University of Cambridge and Shinya Yamanaka of Kyoto University in Japan were to be the recipients was released Oct. 8 in Stockholm, Sweden. More



The role of the cellular entry point of anthrax identified
University of Geneva via PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Anthrax uses a receptor on the surface of cells to inject its lethal toxins. However, the physiological function of this receptor, named Anthrax Toxin Receptor 2a, remained unknown until now. A team led by Marcos Gonzalez-Gaitan, a professor at the University of Geneva, Switzerland, in collaboration with Gisou van der Goot at EPFL, reveals that Antxr2a actually plays a role in embryonic development, orienting cell division along a specific plane, which is a prelude to the formation of future tissues and organs. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
CAP's Histologic Preparations
The "how to" guide to good slide preparation, Histologic Preparations contains troubleshooting techniques for common artifacts and problems incurred in routine histologic preparations.


Observations of 'mechanochemical' synthesis could boost green chemistry
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Solvents are omnipresent in the chemical industry and are a major environmental and safety concern. Therefore the large interest in mechanochemistry: an energy-efficient alternative that avoids using bulk solvents and uses high-frequency milling to drive reactions. Milling is achieved by the intense impact of steel balls in a rapidly moving jar, which hinders the direct observation of underlying chemistry. Scientists have now for the first time studied a milling reaction in real time, using highly penetrating X-rays to observe the surprisingly rapid transformations as the mill mixes, grinds and transforms simple ingredients into a complex product. This study opens new opportunities in green chemistry and environmentally friendly synthesis. More

Inducing stem cells to become different cell types efficiently now possible using a 3-D platform
PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Induced pluripotent stem cells have the potential to form any cell type in the body, providing a powerful tool for drug discovery and regenerative medicine. Yet coaxing these cells to reliably take on a specific fate in the laboratory has proven challenging on a large scale. Now, a team of A*STAR stem cell researchers has developed a cell differentiation protocol in which iPS cells are propagated and expanded in a 3-D bioreactor to efficiently create neural progenitor cells. More


Get your histology CE from MediaLab

Explore our online interactive histology courses, and discover the latest secrets for creating flawless IHC, FISH, special, and routine stains. Complete your annual safety and compliance training hassle free. Document training and get P.A.C.E credits with the included Learning Management System. Get it all with our unlimited annual subscription, available for both individuals and institutions.
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
EndNote X6
EndNote® enables you to move seamlessly through your research process with flexible tools for searching, organizing and sharing your research, creating your bibliography and writing your paper. New in X6: Access your research from anywhere and manage your EndNote library from multiple computers with the new EndNoteSync.
 

Under the Microscope
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