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Human tonsil stained
with anti-IDO-1 antibody

Human ovarian adenocarcinoma stained with anti-B7-H3 antibody

Human tonsil stained
with anti-CD33 antibody

Introducing New Rabbit Monoclonal Antibodies!

Spring Bioscience just released three new rabbit monoclonal antibodies: IDO-1 (SP260), B7-H3/CD276 (SP265) and CD33 (SP266). These highly sensitive and specific Research Use Only (RUO) antibodies are specially engineered for your tissue based research.

      - IDO-1 (SP260): Indoleamine-pyrrole 2,3-dioxygenase (IDO) is an enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-D-kynurenine. High levels of IDO are seen in antigen presenting cells and some tumor cells.

      - B7-H3/CD276 (SP265): B7-H3 (also known as CD276) is a membrane protein that participates in the regulation of T-cellmediated immune response. B7-H3 can activate both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells. High levels of B7-H3 are seen in antigen presenting cells, some tumor cells, and tumor vasculature. It is the target of anticancer immunotherapy.

      - CD33 (SP266): Myeloid cell surface antigen CD33 is an adhesion molecule of myelomonocytic-derived cells. It is expressed by monocytes, macrophages, granulocyte precursors, premyelocytes, myeloid blast, and some tumors such as acute myeloid leukemia and acute monocytic leukemia.

To order or request more information about the new rabbit monoclonal antibodies, visit springbio.com or call (800) 787-6896 or (925) 474-8440. Orders can also be submitted via e-mail at spring.orders@ventana.roche.com. Technical details are available through spring.tech@ventana.roche.com.

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