An altered pattern of liver Apolipoprotein A-I isoforms is implicated in male chronic hepatitis B progression
from The Journal of Proteome Research
Chronic hepatitis B appears to progress more rapidly in males than in females, and CHB-related hepatic cirrhosis and hepatocellular carcinoma are predominately diseases that tend to occur in men and postmenopausal women. To obtain more insight into the underlying mechanisms of gender disparity of CHB progress, two-dimensional difference gel electrophoresis was employed to compare liver proteome of C57BL/6 and HBV transgenic (HBV-Tg) mice both in male and female groups.
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