Editing-molecule mutation causes fatal primordial dwarfism
Fetuses with defects in a molecular machine that edits information cells use to make proteins can develop a rare form of dwarfism, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The defect, triggered by a tiny gene mutation, causes microcephalic osteodysplastic primoridal dwarfism type 1, a rare developmental disorder that greatly slows growth in the uterus and causes severe brain and organ abnormalities, deformities of the arms and legs, and death in infancy or early childhood.
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