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Scientists implicate overlooked amyloid beta peptide in Alzheimer disease pathology

from Genetic Engineering & Biotechnology News

A largely overlooked amyloid-β peptide could play a greater role in the pathogenesis of Alzheimer disease than previously envisaged, scientists claim. Mice engineered to overexpress Aβ43 were found to display impairment of short-term memory and acceleration of amyloid-β pathology. This was accompanied by pronounced accumulation of Aβ43 in plaque cores that were similar in biochemical composition to those observed in the brains of affected human patients. more

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