Role identified for cancer-related genetic elements in glucose metabolism and type 2 diabetes
from Genetic Engineering & Biotechnology News
A role for genetic elements previously implicated in cancer progression has been found in the regulation of metabolism, insulin sensitivity, and the development of diabetes. The RNA-binding proteins Lin28a/b have been shown to promote malignancy by inhibiting let-7 biogenesis, but studies in experimental mice have now demonstrated that overexpression of Lin28a or human LIN28B in mice promotes insulin sensitization that makes the animals resistant to developing high fat diet-induced diabetes.
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