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Scientists Tailor Cell Surface Targeting System to Hit Organelle ZIP Codes

from Medical Xpress

In a paper published in Nature Communications, the team led by researchers at The University of Texas MD Anderson Cancer Center reports packaging the phage particles with a peptide called penetratin to reach inside the cell. This new capacity was used to screen for peptide ligands — binding agents — that connect to receptors on mitochondria, which generate a cell's energy, and ribosomes, which process mRNA to make proteins. The team found a peptide that binds to a specific ribosomal protein called RPL29 which, when delivered with penetratin, disrupts ribosomal function and kills cells. Cell survival was reduced in both malignant and non-malignant cells and in both mouse and human cell lines. more


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