Temporal Wnt Modification Generates Pure Cardiomyocyte Populations from hPSCs
from Genetic Engineering & Biotechnology News
Researchers have developed a protocol for generating almost pure populations of cardiomyocytes from human pluripotent stem cells (hPSCs) simply by modulating canonical Wnt signaling at defined time points in the differentiation process, using readily accessible small molecule compounds. Sean P. Palecek, Ph.D., and colleagues at the University of Wisconsin claim their approach appears far more efficient, reproducible, and inexpensive than existing techniques that require enrichment steps and the use of serum and growth factors.
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