Atorvastatin: A new treatment for periodontal disease?
Periodontal disease is a bacterial infection, and tissue destruction occurs as a consequence of the host immune inflammatory response to oral pathogens. Periodontal pathogens produce harmful by-products and enzymes that break down extracellular matrices, such as collagen, as well as host cell membranes and lead to bone resorption creating bony defects that may cause tooth loss. Current techniques to treat bone defects associated with periodontitis or dental implants consist of surgically placing bone particles or substitutes into the defects to stimulate host bone formation. It also has been suggested that statin use has been associated with decreased tooth loss in chronic periodontitis patients.
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