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Increased mortality with digoxin in AF

from Medscape News

The use of digoxin in patients with atrial fibrillation is being called into question, with the publication of a new study suggesting it is associated with a significant increase in all-cause mortality. The study, a propensity-adjusted analysis of the AFFIRM trial that controlled for multiple comorbidities, was published online on Nov. 27 in the European Heart Journal. It found an overall 41 percent increase in all-cause mortality in patients taking digoxin versus those not taking digoxin. The increase in all-cause mortality was consistently observed in men and women and in patients with and without underlying heart failure. more

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