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Scientists use virus to deliver genetic material to slow children's illness

from The News & Observer

Even if the patients hadn't been as young as 4 months old, the surgery would have been harrowing: six holes bored into the skull, six tiny tubes inserted directly into targeted parts of the brain, then a solution containing hundreds of millions of viruses pumped in. Canavan disease strikes infants, essentially making the brain attack itself with a toxic chemical, stopping and reversing development. It then kills, usually before age 10. The procedure used in the study though, slows Canavan’s progress and improves – and may even help extend – their lives, according to a study that appeared last month in the online journal Science Translational Medicine. more


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