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Bacteria responsible for gum disease facilitates development and progression of rheumatoid arthritis

from University of Louisville

Does gum disease indicate future joint problems? Although researchers and clinicians have long known about an association between two prevalent chronic inflammatory diseases — periodontal disease and rheumatoid arthritis — the microbiological mechanisms have remained unclear. In an article published in PLoS Pathogens, University of Louisville School of Dentistry Oral Health and Systemic Diseases group researcher Jan Potempa and an international team of scientists from the European Union's Gums and Joints project have uncovered how the bacterium responsible for periodontal disease, Porphyromonas gingivalis, worsens RA by leading to earlier onset, faster progression and greater severity of the disease, including increased bone and cartilage destruction. more


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