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Pretransplant sensitization against angiotensin II type 1 receptor is a riskfactor for acute rejection and graft loss

from American Journal of Transplantation

The angiotensin II type 1 receptor is an emerging target of functional non-HLA antibodies. We examined the potential of determining the degree of presensitization against AT1R as a risk factor for graft survival and acute rejection. The study included 599 kidney recipients between 1998 and 2007. Serum samples were analyzed in a blinded fashion for anti-AT1R antibodies using a quantitative solid-phase assay. more

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