Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy
A role for natural killer cells in cardiac allograft vasculopathy was suggested by our earlier observation that CAV arises even in the absence of detectable antidonor T-cell or B-cell reactivity in parental to F1 mouse heart grafts. However, prevention of CAV in this setting required the depletion of both NK and CD4+ T cells.
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