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Sarcoidosis-associated pulmonary hypertension and lung transplantation for sarcoidosis

from Medscape News

Pulmonary hypertension is a significant complication of sarcoidosis, occurring in 6 to 74 percent of patients. The presence of PH markedly increases mortality among these patients; this effect is independent of pulmonary function. As will be discussed in detail later, lung transplantation is a viable therapeutic option for severe pulmonary parenchymal or vascular disease refractory to medical therapy in patients with sarcoidosis, but has significant morbidity and mortality. In this article, we first discuss in depth sarcoidosis-associated PH, including pathogenesis, prevalence, clinical features and therapy. Finally, we discuss LT (results, indications, and identifying appropriate candidates) for sarcoid patients with end-stage fibrocystic disease or SAPH. more

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