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Tumor genomics: Sequence normal tissue, too

from MedPage Today

The standard approach of analyzing malignant tumors for unique genetic mutations to target therapy may not be sufficient and may, in fact, lead to inappropriate treatment, researchers said. For accuracy, tumor genomes should also be compared with matched samples of DNA from patient's noncancerous tissue, concluded investigators led by Sian Jones, Ph.D., of Personal Genome Diagnostics, in Baltimore, who reported their findings online in Science Translational Medicine. more

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