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Mutational profiles of HPV-positive, HPV-negative tumors differ

from Healio

The differences in the genetic profile of HPV-positive and HPV-negative tumors may represent therapeutic targets for cancers of the pharynx and oral cavity, according to findings presented at the ASCO Annual Meeting. Loss-of-function tumor suppressor gene mutations negatively interfered with the efficacy of adjuvant cisplatin-based chemoradiation, whereas activating driver gene mutations were associated with poor risk in HPV-associated squamous cell carcinomas of the head and neck. more

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