Organ transplant rejection isn't always forever
The rejection of transplanted organs in hosts that were previously tolerant may not be permanent, according to new research. Using a mouse model of cardiac transplantation, the researchers found that immune tolerance can spontaneously recover after an infection-triggered rejection event, and that hosts can accept subsequent transplants as soon as a week after. This process depends on regulatory T-cells, a component of the immune system that acts as a "brake" for other immune cells.
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