Cognition unchanged when BP drugs stopped in elderly cohort
In a randomized trial of community-dwelling seniors over age 75 with hypertension and only mild cognitive deficits, stopping antihypertensive therapy for 16 weeks did not improve their short-term cognitive, psychological, or general function. These findings from the Antihypertensive Treatment in Elderly People (DANTE-Leiden) were published online August 24, 2015 in JAMA Internal Medicine. This trial is the first to assess the narrowly defined research question of the effect of discontinuing antihypertensive treatment on cognitive function in older persons, the authors write. "Therefore, we can only conclude that discontinuation of antihypertensive treatment in older persons with mild cognitive deficits and without serious cardiovascular disease has no short-term cognitive benefit."
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