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Study: Rare HER2 missense mutations do not spread breast cancer on their own

from Johns Hopkins Kimmel Cancer Center via News-Medical.Net

Results of a new laboratory study by Johns Hopkins Kimmel Cancer Center researchers suggests that some rare "missense" mutations in the HER2 gene are apparently not — on their own — capable of causing breast cancer growth or spread. In a related finding, the research team said such mutations, which are found in about five percent of breast cancers, may, thus, also fail to predict response to anti-cancer drugs that target the HER2 gene, unlike the more common alterations of the gene that amplify or overexpress it. more

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