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Study: Mechanism regulating breast cancer aggressiveness

from Breast Cancer News

A new study has offered insights into the exact mechanism breast cancer cells undergo in order to become aggressive. The findings, included in the study "Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma," and published in the journal Antioxidants & Redox Signaling, show that the switch to these cells becoming more invasive can be traced all the way back to increased intracellular levels of an enzyme called manganese superoxide dismutase, which is an important regulator of the cells' metabolic redox processes. more

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