Protecting Hearts From Herceptin: MANTICORE Data 'Unclear'
Antihypertensive pharmacotherapy can prevent chemotherapy-related cardiac dysfunction and life-threatening treatment interruptions in patients with invasive early breast cancer given adjuvant trastuzumab, show the now-published results from five-year Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE) trial. However, neither of the pharmacotherapies prevented trastuzumab-mediated concurrent left ventricular (LV) end-diastolic volume — also known as LV remodeling — which was the study's primary endpoint.
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