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Experimental drug targets nucleus of allergen-sensitized cells

from Cincinnati Children's Hospital Medical Center via Lab Manager

Transcription factors, the tiny proteins that switch genes on or off in the nucleus of cells, are considered unreachable molecular targets for drugs attempting to treat medical conditions. Overcoming this challenge, researchers at Cincinnati Children's Hospital Medical Center discovered a small molecular compound that successfully blocks a transcription factor and its pro-inflammatory and hypermucous activity in asthma. more

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