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Chemotherapy and transplantation: The role of immunosuppression in malignancy and a review of antineoplastic agents in solid organ transplant recipients

from American Journal of Transplantation

It is estimated that solid organ transplant recipients have a two- to fourfold greater overall risk of malignancy than the general population. Some of the most common malignancies after transplant include skin cancers and posttransplant lymphoproliferative disorder. In addition to known risk factors such as environmental exposures, genetics, and infection with oncogenic viruses, immunosuppression plays a large role in the development of cancer through the loss of the immunosurveillance process. more

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