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Donor specificity but not broadness of sensitization is associated with antibody-mediated rejection and graft loss in renal allograft recipients

from American Journal of Transplantation

Panel-reactive antibodies are widely regarded as an important immunological risk factor for rejection and graft loss. The broadness of sensitization against HLA is most appropriately measured by the “calculated population-reactive antibodies” (cPRA) value. In this study, we investigated whether cPRA represent an immunological risk in times of sensitive and accurate determination of pretransplantation donor-specific HLA antibodies (DSA). more


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