Doctors cure sickle cell patients using allogeneic stem cells
Under the revised protocol, patients with aggressive sickle cell disease (SCD) can receive stem cells from donors that were previously thought to be incompatible for transplant. Human Leukocyte Antigen (HLA) markers are cell-surface proteins that the immune system uses to distinguish between cells that belong in the body and those that do not. Since these proteins are inherited from parents, family members are the most likely people to have HLA markers that match the patient’s.
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