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ADOPT: Obesity Treatment Reaches Level of Maturity with its Own Collaborative Initiative and Resource

from Wanda Truong and Louis J. Aronne

From March 28: The Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures Working Group, comprised of interdisciplinary scientists with expertise in the behavioral, biological, environmental, and psychosocial domains, was convened by the NIH with the goal of helping researchers better understand individual variability in response to treatment in an effort to develop more personalized and targeted treatments for obesity in adults. Understanding how the mechanisms across these domains interact is critical to identifying targets for treatment and determining when, how, and with whom to intervene to achieve the greatest success. ADOPT proposes a framework for how obesity researchers collectively can generate the evidence base needed to guide the development of effective, tailored strategies for the treatment of obesity.

The ADOPT Working Model is an interdisciplinary framework defining how obesity treatments impact weight loss or weight loss maintenance across the four ADOPT domains, which explains much of the individual variability in treatment response. The ADOPT working group further combined data collection tools that would provide investigators with the most advanced approaches to identify complex processes that affect the treatment of patients with obesity. Each domain’s subgroup reviewed variables measured in adult weight loss trials and identified the current gold standard assessment method used to measure those variables. The four companion papers (4-7) further discuss the identification and selection process of the variables, or “core” constructs, measures, the associated critical knowledge gaps, and limitations of available assessment tools within each domain. Read more here. more

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