Comparable analgesia with low-dose IV ketamine, morphine for acute pain
from Clinical Pain Advisor
In one study, ketamine was administered to patients with long bone fractures at 0.5 mg/kg, and in the other two studies, 0.3 mg/kg ketamine was administered to patients with abdominal, flank or musculoskeletal pain. The researchers noted that the studies had a low risk for bias, but there was significant inconsistency in the reporting of adverse events. The primary outcome was change in mean pain score 10 minutes after treatment. The difference in mean numeric rating scale score between patients treated with ketamine versus morphine was 0.42, indicating that ketamine provided pain relief comparable to that of single-dose IV morphine in these cohorts.
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