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Normal and fibrotic liver parenchyma respond differently to irreversible electroporation

from HPB via Pub Med

The safety and efficacy of irreversible electroporation (IRE) in treating hepatic, biliary and pancreatic malignancies are active areas of clinical investigation. In addition, recent studies have shown that IRE may enable regenerative surgery and in vivo tissue engineering. To use IRE effectively in these clinical applications, it is important to understand how different tissue microenvironments impact the response to IRE. In this study, we characterize the electrical and histological properties of nonfibrotic and fibrotic liver parenchyma before and after IRE treatment. Electrical resistivity and histology of fibrotic liver from C57BL/6 mice fed a 0.1 percent 3,5-diethylcarbonyl-1,4-dihydrocollidine diet were compared to those of nonfibrotic liver from matched control mice before and after IRE treatment. more


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