HIV infant model opens new avenues for research
from Drug Target Review
Researchers have developed an animal model to test HIV infection and therapies in infants, allowing them to develop biomarkers to predict viral rebound after antiretroviral therapy interruption. The new model allows for immune interventions against the HIV envelope protein through the use of a SHIV, as opposed to a SIV, a simian immunodeficiency virus that has a very different virus envelope than HIV. It takes advantage of recent advances in SHIV development that fully replicated the clade C viruses that are involved in the majority of infant HIV transmission.
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