Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
from The Journal of Clinical Investigation
Allograft rejection is unique among immune responses in that it enlists 1–10 percent of the total T cell repertoire, a proportion that up to 1,000 times greater than that observed after microbial infection. The unusual number of T cells involved is attributed to the high frequency of T cells that recognize intact, allogeneic MHC molecules. This pathway of antigen recognition is referred to as “direct” to distinguish it from the “indirect” pathway in which T cells recognize foreign antigens as processed peptides bound to self-MHC molecules.
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