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Craniosacral therapy for chronic pain: A systematic review and meta-analysis of randomized controlled trials

from BMC Musculoskeletal Disorders

The objective of this study was to systematically assess the evidence of Craniosacral Therapy (CST) for the treatment of chronic pain. PubMed, CENTRAL, Scopus, PsycInfo and CINAHL were searched up to August 2018. Randomized controlled trials (RCTs) assessing the effects of CST in chronic pain patients were eligible. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for pain intensity and functional disability (primary outcomes) using Hedges’ correction for small samples. Secondary outcomes included physical/mental quality of life, global improvement, and safety. Risk of bias was assessed using the Cochrane tool. Ten RCTs of 681 patients with neck and back pain, migraine, headache, fibromyalgia, epicondylitis, and pelvic girdle pain were included. CST showed greater post intervention effects on: pain intensity (SMD = -0.32, 95%CI = [− 0.61,-0.02]) and disability (SMD = -0.58, 95%CI = [− 0.92,-0.24]) compared to treatment as usual; on pain intensity (SMD = -0.63, 95%CI = [− 0.90,-0.37]) and disability (SMD = -0.54, 95%CI = [− 0.81,-0.28]) compared to manual/non-manual sham; and on pain intensity (SMD = -0.53, 95%CI = [− 0.89,-0.16]) and disability (SMD = -0.58, 95%CI = [− 0.95,-0.21]) compared to active manual treatments. At six months, CST showed greater effects on pain intensity (SMD = -0.59, 95%CI = [− 0.99,-0.19]) and disability (SMD = -0.53, 95%CI = [− 0.87,-0.19]) versus sham. Secondary outcomes were all significantly more improved in CST patients than in other groups, except for six-month mental quality of life versus sham. Sensitivity analyses revealed robust effects of CST against most risk of bias domains. Five of the 10 RCTs reported safety data. No serious adverse events occurred. Minor adverse events were equally distributed between the groups. In patients with chronic pain, this meta-analysis suggests significant and robust effects of CST on pain and function lasting up to six months. More RCTs strictly following CONSORT are needed to further corroborate the effects and safety of CST on chronic pain. more

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