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α2δ-1 — NMDA receptor interactions are responsible for increases in pain sensitivity caused by opioids

from National Institute on Drug Abuse

This study reported:
  • In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment.
  • Blocking the α2δ-1-1 — NMDA interaction reduced opioid-induced hyperalgesia and analgesic tolerance. more

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