α2δ-1 — NMDA receptor interactions are responsible for increases in pain sensitivity caused by opioids
from National Institute on Drug Abuse
This study reported:
In animal studies, α2δ-1 and its interactions with NMDA receptors in the spinal cord triggered the pain sensitivity and analgesic tolerance that occurs with chronic morphine treatment.
Blocking the α2δ-1-1 — NMDA interaction reduced opioid-induced hyperalgesia and analgesic tolerance.
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