Linking indirect effects of cytomegalovirus in transplantation to modulation of monocyte innate immune function
Cytomegalovirus is an important cause of morbidity and mortality in the immunocompromized host. In transplant recipients, a variety of clinically important “indirect effects” are attributed to immune modulation by CMV, including increased mortality from fungal disease, allograft dysfunction and rejection in solid organ transplantation, and graft-versus-host-disease in stem cell transplantation. Monocytes, key cellular targets of CMV, are permissive to primary, latent and reactivated CMV infection.
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