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Linking indirect effects of cytomegalovirus in transplantation to modulation of monocyte innate immune function

from ScienceAdvances

Cytomegalovirus is an important cause of morbidity and mortality in the immunocompromized host. In transplant recipients, a variety of clinically important “indirect effects” are attributed to immune modulation by CMV, including increased mortality from fungal disease, allograft dysfunction and rejection in solid organ transplantation, and graft-versus-host-disease in stem cell transplantation. Monocytes, key cellular targets of CMV, are permissive to primary, latent and reactivated CMV infection. more


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