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Anti-human leukocyte antigen immune sensitization effects of cryopreserved allograft and blood transfusion

from Journal of Burn Care & Research

Vascularized composite allotransplantation (VCA) is the most advanced reconstructive technique available to patients who suffer devastating burns to the limbs or face. However, VCA requires donor–recipient matching. Burn patients have been reported to experience sensitization, or the development of anti-human leukocyte antigen antibodies, during resuscitation and wound coverage, potentially precluding them from future VCA. more

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