Search for COVID-19 drugs boosted by SARS discovery
from Walter and Eliza Hall Institute of Medical Research via Medical Xpress
An extensive search and testing of current drugs and drug-like compounds has revealed compounds previously developed to fight SARS might also work against COVID-19. Using the National Drug Discovery Center, researchers from the Walter and Eliza Hall Institute identified drug-like compounds that could block a key coronavirus protein called PLpro. This protein, found in all coronaviruses, is essential for the virus to hijack and multiply within human cells and disable their anti-viral defenses. Initially developed as potential treatments for SARS, the compounds prevented the growth of the SARS-CoV-2 virus (which causes COVID-19) in the laboratory. The discovery, published in
The EMBO Journal
, was led by Professor David Komander, Professor Marc Pellegrini, Professor Guillaume Lessene and Dr. Theresa Klemm.
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