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 With 2018 at an end, ACS would like to wish its members, partners and other industry professionals a happy New Year. As we reflect on the past year for the industry, we would like to provide the readers of The Brief a look at the 20 most accessed articles from the year. Here is Part 2. Our regular publication will resume Thursday, Jan. 10.
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Medscape
From March 22: An unexpected finding in women with estrogen receptor-positive (ER+) metastatic breast cancer (MBC) is the emergence of acquired mutations in HER2.
These mutations explain some of the resistance to hormone-directed therapy that is seen in these patients, and the new finding could offer a new approach to clinical management, researchers said at a media preview for the American Association for Cancer Research (AACR) 2018 Annual Meeting.
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Archives of Pathology & Laboratory Medicine
From Sept. 27: In 1993, Black and Welch published a prophetic article that foretold the diagnostic imaging-induced conundrum now known as overdiagnosis. Overdiagnosis is defined as detection of a medical condition that, if left undiagnosed, would cause no harm. Compelled by the above-cited authors and my own experiences, I advocate discussions of cancer overdiagnosis with medical students, house officers and faculty. The potential harms of cancer overdiagnosis include not only unnecessary surgery and complications, but also the emotional and financial tribulations incurred by cancer diagnosis and indefinite follow-up.
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Medical Xpress
From April 19: When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch jams into the "on" position, allowing cells to proliferate uncontrollably.
This unstoppable cascade inevitably leads to cancer.
"The mutation in the gene is very common in pancreatic and colon cancer," said Neil Kelleher, the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences and Medicine at Northwestern University. "But there are currently no drugs that can target the mutation and fix the broken switch."
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Medical Xpress
From Feb. 1: "Knowledge is a key component of decision making, and yet it's consistently low even among patients who have received treatment. We need better tools to make these decisions more informed," says Sarah T. Hawley, Ph.D., MPH, professor of internal medicine at Michigan Medicine.
Hawley and colleagues from the Cancer Surveillance and Outcomes Research Team at the University of Michigan Comprehensive Cancer Center developed an interactive online tool to help patients understand their treatment options.
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Doctors Without Borders/Médecins Sans Frontières (MSF) is actively recruiting general and trauma surgeons with experience in emergency obstetrics for international missions in developing countries. Learn more
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Los Angeles Times
From May 10: In a shift that puts early detection of prostate cancer back on the agenda for middle-aged men and their doctors, a federal panel of experts is recommending that men ages 55 to 69 weigh the potential harms and benefits of prostate cancer screening and judge whether getting tested feels right to them.
A recommendation issued recently by the U.S. Preventive Services Task Force judged the "net benefits" of screening these men for prostate cancer to be small. But the panel said the prostate-specific antigen, or PSA, test should be offered to them "based on professional judgment and patient preferences."
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TIME
From Aug. 30: Cancer is never an easy foe, but some types are more stubborn than others. Ovarian cancer is one of the hardest to treat, but there are signs of progress. Several recent studies have used new combination treatment strategies, including a drug that may make chemotherapy more effective and a drug originally designed to treat breast cancer. More research is needed, but the new studies provide hope for improving outcomes for women with advanced ovarian cancer, when there was little before.
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ACS
The American College of Surgeons (ACS) applauds the U.S. House of Representatives on passage of the Mission Zero Act (H.R. 880). This ACS-supported legislation establishes a grant program to assist civilian trauma centers in partnering with military trauma professionals to create a pathway to provide patients with the highest quality of trauma care in times of both peace and war.
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Medical News Today
From Aug. 2: Groundbreaking laboratory-grown prostate cancer cells could change the way research is carried out. They will significantly increase the speed at which new drugs can be trialed. Aside from skin cancer, prostate cancer is the most common cancer in the United States, with around 164,000 new cases each year.
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U.S. News & World Report
From July 26: Lung cancer is the deadliest form of cancer for a few reasons. First, it's the second most commonly diagnosed form of cancer behind only skin cancer. The American Cancer Society reports that about 14 percent of all new cancers are diagnosed in the lungs and estimates that in the U.S. in 2018, 234,030 new cases of lung cancer will be diagnosed and about 154,050 people will die of the disease. That accounts for more than a quarter of all cancer deaths in the U.S.
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Oncology Nurse Advisor
From June 7: Many palliative care programs utilize interventions such as music and art therapy. These programs provide benefits that augment traditional medicine and have become increasingly popular. Creative art therapy (CAT) comprises a number of artistic concepts: music, dance and movement, yoga, drama, and even creative writing and poetry. Art, however, is the most significant modality because it actually is a psychosocial intervention.
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Disclaimer: The Brief is a digest of news selected for the Commission on Cancer (CoC) and the National Accreditation Program for Breast Centers (NAPBC), both quality programs of the American College of Surgeons, from thousands of sources by the editors of MultiBriefs, an independent organization that also manages and sells advertising. The Cancer Programs do not endorse any of the advertised products and services. Opinions expressed in the articles are those of the authors and not of the American College of Surgeons, and the Cancer Programs.
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