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Medical Xpress
A researcher at Syracuse University has simple advice for breast cancer survivors struggling with the side effects of Aromatase Inhibitors (AIs): exercise.
Gwendolyn Thomas, assistant professor of exercise science, is the co-author of a groundbreaking article in the Obesity Journal (The Obesity Society, 2017) about the effects of exercise and physical activity on postmenopausal breast cancer survivors taking AIs — hormone-therapy drugs that stop the production of estrogen. She contends that a combination of resistance and aerobic exercise helps mitigate the side effects of AIs and improves health outcomes in breast cancer survivors, particularly their body composition.
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Chicago Tribune
"Chemo brain" — the mental fog common after breast cancer treatment — can persist for six months, new research shows.
The finding comes from one of the largest studies to date to look at chemotherapy-related thinking problems that plague many women treated for breast cancer. Those problems can include memory lapses, attention issues and difficulty processing information. When researchers compared hundreds of U.S. women six months after chemotherapy ended with hundreds of healthy women, they found more than one-third of the chemotherapy group had a decline in thinking scores versus less than 15 percent of the others.
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CoC and NAPBC
World Cancer Day is an international day marked on Feb. 4 to raise awareness of cancer and to encourage its prevention, detection and treatment. World Cancer Day is an initiative of the Union for International Cancer Control (UICC) with a goal to significantly reduce illness and death caused by cancer by 2020.
The Commission on Cancer (CoC) and the National Accreditation Program for Breast Centers (NAPBC) encourage your program to observe World Cancer Day and use this as an opportunity to display/promote your CoC and NAPBC accreditation status.
To help you promote this event within your program and the community, the CoC and the NAPBC have developed a poster that you can download and print. Programs that hold CoC or both CoC and NAPBC accreditations can access the poster by going to CoC Datalinks and clicking on Marketing CoC Accreditation. For programs that are solely NAPBC-accredited, please use the link to the Marketing Resources website provided in your performance report email notification.
Additional resources can be found on the World Cancer Day website.
Medscape
The first large-scale analysis to compare upfront surgery to definitive chemoradiation (CRT) in patients with human papilloma virus (HPV)-negative oropharyngeal squamous cell cancer (OPSCC) found no difference in overall survival between the two groups.
Patients receiving CRT had a three-year overall survival of 79.2 percent compared with 81.4 percent for those who underwent primary surgery, report Zain A. Husain, M.D., of Smilow Cancer Hospital, Yale Cancer Center, New Haven, Connecticut and colleagues.
However, nearly 60 percent of patients treated with upfront surgery also received adjuvant CRT, which is notable, say the authors, as trimodal therapy likely worsens toxic effects without a discernable survival benefit.
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Wiley Online Library
The American Joint Committee on Cancer (AJCC) staging manual has become the benchmark for classifying patients with cancer, defining prognosis, and determining the best treatment approaches. Many view the primary role of the tumor, lymph node, metastasis (TNM) system as that of a standardized classification system for evaluating cancer at a population level in terms of the extent of disease, both at initial presentation and after surgical treatment, and the overall impact of improvements in cancer treatment.
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ACS
Advances in diagnostic imaging technology have meant that more trauma patients are being diagnosed with blunt cerebrovascular injuries, and as a result, stroke and related death rates in these patients have declined significantly over the past 30 years. These changes are due to the evolution of imaging technology, namely CT-scanning, and its wide availability in hospitals large and small, according to a new study from the University of Tennessee Health Science Center, Memphis, published online in the Journal of the American College of Surgeons in advance of print publication later this year.
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NAPBC
Plan now to attend the National Accreditation Program for Breast Centers (NAPBC) Accreditation Workshop: Pursuing Excellence through NAPBC Accreditation in Chicago on May 5. Watch your email for detailed program information or click here and have your name added to our program interest list.
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Doctors Without Borders/Médecins Sans Frontières (MSF) is actively recruiting general and trauma surgeons with experience in emergency obstetrics for international missions in developing countries. Learn more.
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If you are attending the ASCO Survivorship Symposium, Jan. 27-28 in San Diego at the Manchester Grand Hyatt, make sure to view the poster board G5 The Commission on Cancer's survivorship care plan standard: Implementation is underway, authored by Nina Miller, Cancer Liaison Initiative Manager, Commission on Cancer, American College of Surgeons. Nina and her poster session will be in the Grand Hall Section C from 12:15-1:45 p.m. and 5:15-6:15 p.m. on Friday, Jan. 27.
ModernMedicine
A dendritic cell vaccine that targets HER2 protein may induce an immune response leading to regression of early-stage breast tumors, according to results of research from the Moffitt Cancer Center published in Clinical Cancer Research.
Fifty-four HER2-positive patents were enrolled in a neoadjuvant HER2 peptide-pulsed DC1 vaccine trial. Of the enrolled patients, 42 had ductal carcinoma in situ (DCIS) and 12 had early invasive breast cancer (IBC). The patients were randomized to receive intralesional (IL, n = 19), intranodal (IN, n = 19), or both intralesional and intranodal (ILN, n =16) injection. Responses were measured in peripheral blood and sentinel lymph nodes by in vitro sensitization assay or ELISPOT. Resected surgical specimens were assessed to determine pathologic response.
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CoC-NCDB
The National Cancer Database (NCDB) announces that the Participant User File (PUF) application will open Jan. 23. The NCDB will accept applications for site specific files, which include cases diagnosed between 2004 and 2014. The application period will be open through Feb. 24.
The NCDB PUF is a Health Insurance Portability and Accountability Act (HIPAA) compliant data file containing cases submitted to the Commission on Cancer's (CoC) NCDB and complies with the terms of the Business Associate Agreement between the American College of Surgeons and cancer programs accredited by the CoC; i.e., no patients or facilities can be identified. The PUF is designed to provide investigators at CoC-accredited cancer programs with a data resource they can use to review and advance the quality of care delivered to cancer patients through analyses of cases reported to the NCDB.
For more information, review the PUF Website.
Questions regarding the NCDB PUFs or the RFA process for a PUF may be directed to NCDB technical staff at NCDB_PUF@facs.org.
Forbes
Among partners of young women with breast cancer, anxiety is common — affecting over 42 percent of survey respondents — and may occur years after diagnosis. That's according to a new study of partners of women who received a breast cancer diagnosis before age 40. This report is one of the first to examine the psychological and social issues affecting family members of people with cancer.
Nancy Borstelmann, MPH, LICSW, directs the department of social work at Boston's Dana Farber Cancer Institute, will present the findings at the 2017 Cancer Survivorship Symposium in San Diego.
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CoC
Plan now to attend the 2017 ACS Cancer Programs Annual Conference, Sept. 8-9 in Chicago. The conference will cover content from all areas of the American College of Surgeons Cancer Programs - American Joint Committee on Cancer, the Clinical Research Program, Commission on Cancer, National Accreditation Program for Breast Centers, and the National Cancer Database. Further details on this event will be available soon. Click here to be added to the mailing list for the annual conference. (Please note: The 2017 ACS Cancer Programs Annual Conference replaces the educational event traditionally held in June.)
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ACS
The American College of Surgeons (ACS), in association with Pfizer Inc., is accepting nominations for the 2017 Surgical Volunteerism Award(s) and Surgical Humanitarian Award. All nominations must be received by Feb. 28. Information about the awards and nominations is available online. Contact ogb@facs.org with any questions.
Medical Daily
A class of drugs already approved by the U.S. Food and Drug Administration for treating certain types of cancer may also prevent triple-negative breast cancer from spreading, according to a study published in Nature Communications.
Several breast cancer treatments target what are known as receptors in cancer cells, including estrogen, protesterone, and the HER-2/neu gene, however, the triple-negative form doesn't have these receptors, so the treatments don't have targets, and aren't effective, according to the Mayo Clinic, which conducted the research. Triple-negative breast cancer does have CDK 4/6, which regulates a protein known as SNAIL, which is linked to cancer metastasis. A class of drugs that inhibits CDK 4/6 could also stop triple-negative breast cancer from spreading.
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CoC
The Commission on Cancer is hosting a paper competition for physicians-in-training to foster the importance of oncologic research in support of its mission. Papers are due June 30, 2017.
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Disclaimer: The Brief is a digest of news selected for the Commission on Cancer (CoC) and the National Accreditation Program for Breast Centers (NAPBC), both quality programs of the American College of Surgeons, from thousands of sources by the editors of MultiBriefs, an independent organization that also manages and sells advertising. The CoC and NAPBC do not endorse any of the advertised products and services. Opinions expressed in the articles are those of the author and not of the American College of Surgeons, the CoC and the NAPBC.
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