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Medscape
The detection of polyps and adenomas doubles when colonoscopy screening begins at age 45 instead of age 50, whether or not people have a personal or family history of polyps or cancer, results from a new study show.
"Colonoscopy screening programs for average-risk populations usually enroll patients over 50 years, but we routinely detect polyps or cancer before age 50," said David Karsenti, MD, from the Clinique de Bercy in Charenton le Pont, France.
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Oncology Nurse Advisor
Patients with acute myeloid leukemia who are older than 60 years had optimistic outlooks for curation likelihood and an overestimation of treatment risks that were both at odds with the outlooks of their oncologists, according to study results to be presented at the 2017 Palliative and Supportive Care in Oncology Symposium.
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American College of Surgeons
One of the first studies testing the effectiveness of different operating room head coverings in preventing airborne contamination has found that surgeons' caps that expose small amounts of the ears and hair are not inferior to the bouffant-style, disposable scrub hats that cover those features. Results of the study were presented during a Scientific Forum session at the American College of Surgeons Clinical Congress 2017, and will be published online on the Journal of the American College of Surgeons website, in advance of print publication.
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American College of Surgeons
New study finds that small percentage of cases of flat epithelial atypia upgrade to cancer at surgery.
CHICAGO (October 31, 2017): The detection of certain non-cancerous “high risk” breast lesions can lead to surgical treatment in women, but one of the largest studies of a specific type of high-risk lesion, flat epithelial atypia, calls for close observation, rather than surgical removal of these lesions in most cases, according to study results published on the web site of the Journal of the American College of Surgeons in advance of print.
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ACS-AJCC
The AJCC has announced upcoming live webinars covering topics from the AJCC Staging Manual Eighth Edition for registrars. The schedule is as follows: December 7, 2017 -Introduction & Descriptors; February 15, 2018 -Minor Rule Changes; March 20, 2018 - Major Rule Changes; April 17, 2018 - CAnswer Forum & Staging Questions; July 25, 2018 - Head and Neck Staging; September 6, 2018 -Breast Staging. All webinars will be held from 1-2 pm CT. Make sure to mark your calendars. Additional information and registration links coming soon. Earn FREE Category A CE credits for the live or recorded webinars. Visit the AJCC website for updates.
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JNCCN
Palliative chemotherapy for advanced bladder cancer is recommended in clinical practice guidelines. Patterns of care in routine clinical practice have not been well described. This article describes use rates of chemotherapy and referral rates to medical oncology in the last year of life among patients who have died of bladder cancer.
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ACS- AJCC
Donna Gress, RHIT, CTR, of the American Joint Committee on Cancer (AJCC) has recorded a series of webinars developed for and delivered to the National Program of Cancer Registries (NPCR) Education Training Coordinators (ETC). NPCR has agreed to share these recordings and handouts with the registrar community. These webinars provide information on the assignment of stage, clarification of classification criteria with procedure/treatment differences and special concerns and highlight:
- Exceptions for T, N and M
- When biopsy is considered clinical versus pathologic
- Review and examples of when to use blank versus X
- Details based on common questions related to the anatomic site
- Case scenario, sometimes highlighting missing or incomplete information
Click here to start reviewing the webinars.
Webinars are free. Continuing education (CE) hours were not pre-approved for these webinars.
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Medscape
Triple negative is a term applied to breast cancers that do not meaningfully express the estrogen or progesterone hormone receptors or overexpress the human epidermal growth factor receptor 2 tyrosine kinase. At present, the only proven method for systemic management of triple-negative breast cancer for both early-stage and metastatic settings is cytotoxic chemotherapy. Here, we provide a comprehensive review of management strategies that are best supported by available data. Wealso review recent advances most likely to affect treatment of triple-negative breast cancer in the coming years with particular emphasis on targeted agents, biologics, and immunotherapy.
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Medical News Today
Obesity is a known risk factor for breast cancer, but precisely how does excess weight drive the disease? A new study has shed some light, revealing the process by which obesity increases the aggression of breast cancer cells. By studying mouse and human breast cancer tissue, researchers discovered an increase in blood levels of specific cytokines — which are proteins secreted by immune cells — that reduce the activity of an enzyme called acetyl-CoA-carboxylase 1.
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Novodiax is soon bringing to market 10-minute fast, sensitive and simple Immunoassay (IHC) kits for in vitro diagnostic use to address unmet needs in the intraoperative surgical oncology sector. Learn More
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HealthDay via WebMD
Knowing they're at increased risk for breast cancer isn't enough to persuade many women to get MRI screenings -- even if they're free.
Researchers studied more than 1,000 women in a U.S. military health system who had a 20 percent or greater lifetime risk of breast cancer due to genetics or personal or family history.
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Cancer Network via Modern Medicine
Extended aromatase inhibition (AI) following sequential endocrine therapy did not significantly improve disease-free survival (DFS) among women with hormone receptor HR-positive breast cancer, according to the DATA study. Subgroup analyses indicated, however, that certain high-risk patients may benefit from AI therapy beyond 5 years.
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Doctors Without Borders/Médecins Sans Frontières (MSF) is actively recruiting general and trauma surgeons with experience in emergency obstetrics for international missions in developing countries. Learn more.
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University of Minnesota Medical School via ScienceDaily
New data from a Phase I clinical trial led by Clark Chen, MD, PhD, Lyle French Chair in Neurosurgery and Head of the University of Minnesota Medical School Department of Neurosurgery, shows more than a quarter of patients with recurrent high-grade glioma, a form of brain cancer, were alive more than three years after treatment.
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Healio
Many patients with colon cancer do not receive a blood test that potentially could alter their treatment decisions and improve survival outcomes, according to study results.
“The decision to give a patient chemotherapy after surgery is not a light one, and physicians must weigh the risks and benefits,” Kellie L. Mathis, MD, colon and rectal surgeon at Mayo Clinic in Rochester, Minnesota, said in a press release. “We are currently using the blood test to help make these difficult decisions, and we suggest other physicians do the same.”
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Cancer Network via Modern Medicine
Women with early breast cancer have varying outcomes with zoledronic acid treatment depending on MAF positivity, according to the AZURE trial. MAF-negative patients appear to derive benefit from the bisphosphonate therapy, while MAF-positive patients have poorer outcomes with this treatment.
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Reuters
Tesaro Inc recently said that the U.S. Food and Drug Administration approved an intravenous version of its drug to treat chemotherapy-induced nausea and vomiting in adults.
The intravenous version of the already-approved drug, Varubi, will be used in combination with other agents to prevent delayed nausea and vomiting associated with some forms of chemotherapy, the company said in a statement.
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University of Pennsylvania School of Medicine via ScienceDaily
Pediatric patients with head and neck cancer can be treated with proton beam therapy instead of traditional photon radiation, and it will result in similar outcomes with less impact on quality of life. Researchers from the Perelman School of Medicine at the University of Pennsylvania as well as Children's Hospital of Philadelphia analyzed cases of pediatric head and neck cancer treated with PBT between 2010 and 2016 and found similar rates of tumor control and lower rates of toxicity than what is historically expected from photon radiation. They published their findings recently in the journal Pediatric Blood and Cancer.
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University of Pennsylvania School of Medicine via ScienceDaily
Screening for tumor cells in the fallopian tubes of women at high risk for ovarian cancer may help detect the cancer years before it develops further, suggests a new study. The work traces the origins of high-grade serous ovarian carcinoma, the most frequent type of ovarian cancer that is often diagnosed at advanced stages, back to fallopian tube lesions known as 'p53 signatures' and serous tubal intraepithelial carcinomas that harbor the TP53 gene mutations.
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The Brief
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Disclaimer: The Brief is a digest of news selected for the Commission on Cancer (CoC) and the National Accreditation Program for Breast Centers (NAPBC), both quality programs of the American College of Surgeons, from thousands of sources by the editors of MultiBriefs, an independent organization that also manages and sells advertising. The CoC and NAPBC do not endorse any of the advertised products and services. Opinions expressed in the articles are those of the author and not of the American College of Surgeons, the CoC and the NAPBC.
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