ASCLS Touch Briefings Journals
U.S. Endocrinology — Volume 6 Share
ASCLS collaborates with Touch Briefings to bring ASCLS members free access to the latest eBook versions of the following journals: U.S. Oncological Review Volume 6, U.S. Cardiology Volume 7 issue 2, U.S. Endocrinology Volume 6.
For more information on Touch Briefings' clinical journals, please visit: www.touchoncology.com, www.touchcardiology.com and www.touchendocrinology.com. More
Thrombotic thrombocytopenic purpura and urinary tract infections: Is there a connection?
American Journal of Clinical Pathology via Medscape Share
Idiopathic thrombotic thrombocytopenic purpura, a thrombotic microangiopathic anemia, has no known stimulus. The disease, commonly seen in previously healthy people, is characterized by microangiopathic hemolytic anemia and thrombocytopenia without any other likely causes. Most patients with idiopathic TTP have a deficiency in activity of ADAMTS13, a von Willebrand factor -cleaving pro-tease, and demonstrate an associated autoantibody. Before the routine use of therapeutic plasma exchange to treat patients with TTP, the mortality was approximately 90 percent. More
Blocking a gene stops cancer cells spreading
A gene which encourages cancer to move around the body has been discovered. Experiments on tissue cultures, published in Oncogene, suggest that blocking it would prevent cancers spreading. The researchers hope their work will lead to a new generation of cancer drugs within the decade. More
California's City of Hope team develops 'smart bomb'
to neutralize HIV
San Jose Mercury News Share
After several years in the lab, researchers at City of Hope in Duarte, Calif., are reporting positive results in animal trials of a new treatment designed to both hunt down HIV-infected cells and stop the virus from spreading, according to a study published in the journal, "Science Translational Medicine." John Rossi, chair of molecular and cellular biology at City of Hope and a lead author on the study, likens the molecular compound his team designed to a "smart bomb." It works against the virus itself, while delivering a potent "weapon" to the inside of infected cells, where HIV multiplies. More
No effect from IV iron added to ESA, in contrast to previous studies
Medscape Medical News Share
A new study — the largest to date — has found no additional effect from adding intravenous (IV) iron to an erythropoiesis-stimulating agent (ESA) in cancer patients with chemotherapy-associated anemia. The study, by David Steensma, MD, and colleagues at the Dana-Farber Cancer Institute, Harvard Medical School in Boston, appears in the the Journal of Clinical Oncology. The negative result is in sharp contrast to a number of positive studies that have shown benefit from adding IV iron in this setting, as previously reported by Medscape Medical News. More
Rapid stem cell culture promises cartilage repair
Laboratory News Share
Researchers from the University of Manchester and Central Manchester NHS Foundation Trust took human embryonic stem cells and developed a culture procedure programming the cells' development with a timed series of culture conditions containing different added nutrients to ensure they only produced chondrocytes — the cells that go on to form cartilage. More
Antibodies help seriously ill H1N1 patients recover
Patients who fell severely ill with the pandemic H1N1 flu responded well when treated with antibodies harvested from survivors of the disease, a study in Hong Kong has found. The finding, published in the journal Clinical Infectious Diseases, underlines the importance of using antibodies from recovered patients to treat critically ill people who fail to respond to standard drugs, said lead author Kwok-yung Yuen, a virologist at the University of Hong Kong. More
Bird flu detected on Japanese chicken farm
United Press International Share
The slaughter of more than 10,000 chickens was ordered recently on a Japanese farm after avian influenza was detected in six birds, officials said. The prefectural government in Miyazaki also imposed a six-mile quarantine area around the farm where the infected birds were found, The Mainichi Daily News reported. That means no eggs or birds can be transferred within the area until the restrictions are lifted. More