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Gene 'relocation' key to most evolutionary change in bacteria ScienceDaily Share     In a new study, scientists at the University of Maryland and the Institut Pasteur show that bacteria evolve new abilities, such as antibiotic resistance, predominantly by acquiring genes from other bacteria. The researchers new insights into the evolution of bacteria partly contradict the widely accepted theory that new biological functions in bacteria and other microbes arise primarily through the process of gene duplication within the same organism. More
Next-generation sequencing opens way to broad-scale prenatal and carrier testing Medscape Medical News Share
A new study reports the development of a test panel using next-generation sequencing to detect carriers of more than 400 severe recessive childhood diseases. The screening is far less expensive than complete genome sequencing and detects the designated mutations with 95 percent sensitivity and nearly100 percent specificity. More Screening tool for bleeding disorders in women with menorrhagia performs well Reuters via Medscape Medical News Share
A short eight-question screening tool, coupled with either a serum ferritin level and/or the pictorial blood assessment chart (PBAC) score, can help gynecologists and primary care providers identify women with menorrhagia who should be evaluated for a possible bleeding disorder, a new study finds. "Undiagnosed bleeding disorders, such as von Willebrand disease and platelet function defects, are common in women with menorrhagia and may impact women's lives adversely because of bleeding complications after childbirth and surgery, blood transfusions, and chronic iron deficiency anemia," the study team notes in the American Journal of Obstetrics and Gynecology. More Study finds genetic commonality between Celiac disease and Crohn's disease BioNews Share
An international team of scientists has discovered that people with celiac disease and Crohn's disease share a number of common genetic loci. The researchers carried out a combined meta-analysis of genome-wide association study data from two large studies, one on each condition, and identified four 'risk loci' in common. More
'Artificial pancreas' shows promise in pregnancy Reuters UK Share
Scientists have shown how an "artificial pancreas" can help pregnant women with type 1 diabetes and say their finding could significantly reduce cases of stillbirth and death among diabetic expectant mothers. British researchers used a so-called "closed-loop insulin delivery system" or artificial pancreas, in 10 pregnant women with Type 1 diabetes and found it provided the right amount of insulin at the right time, maintained near normal blood sugar, and prevented dangerous drops in blood sugar levels at night. More Earlier hormone therapy elevates risk of breast cancer The New York Times Share
Growing evidence about the risks of breast cancer and other serious illnesses posed by hormone therapy for menopause has led many women to give up the drugs, and many doctors to stop recommending them. But there has been a lingering belief that for younger women in the early stages of menopause, hormone risks may be negligible, at least for a while. So those who are really suffering from hot flashes, insomnia and other symptoms are often told that it is probably all right to take the drugs, as long as they use the lowest possible dose for the shortest possible time. More Compound offers novel approach to inhibit cancer cell growth Clinical Lab Products Share
MedImmune's Oncology group has announced preclinical results showing that MEDI-573, a targeted monoclonal antibody, broadly suppresses pathways that have been shown to play a critical role in the development and progression of many solid tumors. The study, published in Cancer Research, the journal of the American Association for Cancer Research, suggests that MEDI-573 inhibits multiple biological pathways related to cancer. More
Study: Gene protects US blacks from heart disease Reuters Share
Some black Americans have a gene that protects them from heart disease, researchers said. About a quarter of African-Americans carry the protective gene, and if they are lucky enough to have two copies, one from each parent, their risk of heart disease is 10 times lower that of other blacks. People with just one copy have five times lower the risk of heart attacks, blocked arteries and other symptoms of heart disease, the team reported in the Journal of Human Genetics. More Novel gene test effective in identifying primary tumor sites Medscape Medical News Share
Real-world data have confirmed the effectiveness of a test designed to help identify the primary tumor site in patients with difficult-to-diagnose cancers. After using the novel gene-expression-profile assay, the determination of the primary diagnosis site and treatment management was altered in more than half of the patients in a new study. More |
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