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Washington University School of Medicine via ScienceDaily
About 1.5 million people died of tuberculosis in 2017, making it the most lethal infectious disease worldwide. A growing rise in drug-resistant tuberculosis is a major obstacle to successfully treating the illness. Now, researchers at Washington University School of Medicine in St. Louis and Umea University in Sweden have found a compound that prevents and even reverses resistance to isoniazid, the most widely used antibiotic for treating tuberculosis.
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Los Angeles Times
People with a DNA mutation that reduces their chance of HIV infection may die sooner, according to a study that suggests tinkering with a gene to try to fix one problem may cause others.
The study authors cited the case of the Chinese researcher who tried to produce this mutation in twin girls before their birth in an attempt to reduce their risk for HIV.
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American Chemical Society via Lab Manager
According to the Mayo Clinic, about 20% of breast cancers make abnormally high levels of a protein called human epidermal growth factor receptor 2. When displayed on the surface of cancer cells, this signaling protein helps them proliferate uncontrollably and is linked with a poor prognosis.
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Trinity College Dublin via Infection Control Today
Scientists from Trinity College Dublin have discovered how the highly infectious and sometimes deadly hepatitis C virus "ghosts" our immune system and remains undiagnosed in many people. They recently reported their findings in the international FASEB journal. Hepatitis C's main route of transmission is via infected blood, but over the past 40 years it has accidentally been given to many patients across the world via infected blood products.
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The miniiSED™ is the newest addition to the iSED™ family of ESR analyzers from ALCOR Scientific. The miniiSED™ is a single position, fully automated ESR analyzer that works directly from the primary EDTA tube and produces an ESR result in just 15 seconds. The miniiSED™ is the ideal ESR analyzer for small laboratories, POL’s and emergency clinics.
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University of Edinburgh via ScienceDaily
The fight against superbugs could be helped by the discovery of a potential therapy based on the body's natural immune defences. Scientists have found that a molecule produced by the body — called LL-37 — changes the way cells behave when they are invaded by bacteria. The molecule acts like a fire alarm, experts say, warning the body's immune system of the infection and the need for urgent action.
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ScienceAlert
For the first time, scientists have managed to genetically modify stem cells inside the bodies of mice, a feat which could eventually open up new potential in stem cell therapy.
Stem cells can develop into all kinds of other cells, and the body uses these diverse tools for both growth and repair. Because of their remarkable abilities, there's interest in using stem cells for certain medical treatments, but that road is not always easy.
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CIDRAP
A new World Health Organization analysis of Ebola infections in children under 5 years old in the Democratic Republic of the Congo's outbreak found that parents often avoid taking them to Ebola treatment centers and that the youngsters are less likely than other groups to be added to contact tracing lists. In other outbreak developments, the DRC's health ministry in recent updates said Ebola has infected 29 more people, one of them a health worker who died from the disease.
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Dark Daily
Dark Daily has long predicted that multiomics will someday play an important role in clinical laboratory diagnostic medicine. Now, new research from St. Jude Children’s Research Hospital provides early evidence of that prediction coming to fruition.
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Five Levels of recovery with LGC Maine Standards’ family of liquid-ready, VALIDATE® Hemostasis products: D-Dimer, Fibrinogen, Heparin Anti-Xa. Meeting calibration verification regulatory requirements for calibrated test methods has never been easier.
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With the demand for STAT samples at an all-time high, Drucker Diagnostics’ DASH centrifuges make reducing TAT easier than ever. Choose our set-and-lock Apex models for maximum repeatability or monitor cycle status to the last second with the Flex 12’s digital countdown. Push-button operation, lid lighting system, and more.
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Ann & Robert H. Lurie Children's Hospital of Chicago via ScienceDaily
Preschool children with community-acquired pneumonia often receive unnecessary tests and treatment at outpatient clinics and emergency departments, according to a nationally representative study led by Dr. Todd Florin from Ann & Robert H. Lurie Children's Hospital of Chicago. While most cases of community-acquired pneumonia in young children are caused by viruses, for which antibiotics provide no benefit, antibiotics were prescribed in nearly 74% of outpatient visits.
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Inserm via Lab Manager
The global spread of antibiotic resistance is a major public health issue and a priority for international microbiology research. In his paper published in the journal Science, Christian Lesterlin, Inserm researcher at Lyon’s Molecular Microbiology and Structural Biochemistry laboratory (CNRS/Université Claude Bernard Lyon 1), and his team were able to film the process of antibiotic resistance acquisition in real time, discovering a key but unexpected player in its maintenance and spread within bacterial populations.
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To find out how to feature your company in the ASCLS eNewsletter and other advertising opportunities, contact Andy Keith at 972-402-7707.
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SeraSub® is a synthetic serum for use as a component in preparing standards and controls for in-vitro diagnostic tests. Learn more
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Pittsburgh Quarterly
Ever since her Peace Corps days in Uganda, Libby Ernharth has been fascinated by infectious diseases. In Africa in the 1990s, she first saw the havoc wreaked when parasites and other tiny organisms make their way inside of human hosts. Later, when she became a physician assistant in Pittsburgh, she dealt mainly with “first-world infections — the consequences of our diets, of our smoking, our chemotherapies and our medications.”
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Medical News Today
Some drugs work well for one person but are ineffective for another; some also produce adverse events for certain individuals but not others. A study, using human gut bacteria and a mouse model, investigates whether our gut bacteria might help explain why.
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