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Medical News Today
Oxidative stress is a phenomenon that occurs at a cellular level, and which can drive previously healthy cells to deteriorate and eventually die. Cancer often uses oxidative stress to its own benefit, but could this phenomenon be turned against it?
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Streck
Understanding bacterial mechanisms that contribute to antimicrobial resistance is important for early detection of infections. β-lactamase production is the most frequent mechanism of resistance. Molecular classification of β-lactamases requires sequence determinations of either the gene encoding the enzyme or the amino acid sequence of the protein. Two Streck ARM-D® Kits detect 13 gene families and 450 allelic variants within β-lactamase and ampC families. The kits enable detection of antimicrobial resistance in the most accurate, fast and cost efficient manner. View Poster
BBC News
Scientists in Cambridge, England, say advances in genetics are set to transform the treatment of breast cancer, making it more personalized to each patient.
All women there diagnosed with breast cancer have their entire genetic code mapped.
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Walter and Eliza Hall Institute via ScienceDaily
Scientists have taken a significant step toward developing a new vaccine for malaria, revealing for the first time an "atomic-scale" blueprint of how the parasite invades human cells. Using the Nobel Prize-winning technology cryo-electron microscopy, the researchers mapped the previously hidden first contact between Plasmodium vivax malaria parasites and young red blood cells they invade to begin the parasites' spread throughout the body.
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LGC Maine Standards offers VALIDATE® HbA1c for Easier Linearity and Calibration Verification
VALIDATE® HbA1c is a liquid, easy-to-use kit that tests linearity for % Glycohemoglobin A1c in a human whole blood base matrix. VALIDATE® virtually eliminates dilutions while maximizing reportable ranges. Visit www.mainestandards.com or call 1-800-377-9684 for more information.
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American Academy of Family Physicians
The World Health Organization recently released its first list of essential diagnostic lab tests to improve diagnosis and treatment outcomes worldwide. The list, titled "WHO Model List of Essential In Vitro Diagnostics," focuses on in vitro tests, or tests of human specimens such as blood and urine, and outlines 113 products.
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MedPage Today
Only about 60 percent of U.S. adults with recent HIV-related risk behaviors were ever tested for the virus, and those high-risk individuals who have been tested are not getting tested as frequently as recommended, researchers found.
A total of 62.2 percent of adults with HIV-risk behaviors in the last 12 months reported being ever tested for HIV, and the median estimated interval since the last HIV test for this population was 512 days (1.4 years) — exceeding the recommendation for annual testing, reported Marc A. Pitasi, an epidemiologist in Atlanta, and colleagues.
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University of California, San Francisco via Lab Manager
In a new study published online June 25 in Nature Medicine, University of California, San Francisco researchers have identified a key biological pathway in human cancer patients that appears to prime the immune system for a successful response to immunotherapy drugs known as checkpoint inhibitors. The findings, including initial observations from human tumor samples, mechanistic studies in mouse models, then confirmation in additional patient samples, could better enable clinicians to predict which patients will naturally benefit from these promising new treatments, and potentially to modify the immune response in other patients to allow more people to benefit from these therapies.
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Infection Control Today
Treatment duration, treatment interval, formulation and type of antimicrobial (antibiotic) are modifiable factors that will influence antimicrobial selection pressure. Currently, the impact of the route of administration on the occurrence of resistance in humans is unclear.
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HealthDay News
People believed to have a penicillin allergy are often prescribed much stronger antibiotics that can raise their risk for dangerous infections, a new study suggests.
But testing folks to make sure they really are allergic to penicillin could lower that danger, the researchers added.
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DARK Daily
Through microfluidics and automation, clinical laboratories and anatomic pathologists have been able to detect ever-smaller quantities of biomarkers and other indicators of chronic disease.
However, preserving sample quality is an essential part of analytical accuracy. This is particularly true in precision oncology and other specialties where isolating rare cells, such as circulating tumor cells, is a key component to obtaining information and running diagnostics.
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News-Medical.Net
A new study by Professors Martti Juhola and Katriina Aalto-Setälä of the University of Tampere in Finland demonstrates that with the use of artificial intelligence and machine learning, it is possible not only to accurately sort sick cardiac cell cultures from healthy ones, but also to differentiate between genetic cardiac diseases.
iPSC-derived cardiomyocytes can be derived from a blood sample or a skin biopsy.
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