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Genetically engineered T cells show promise in B cell malignancies
Medscape Medical News
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Results from a small early-stage study reveal a promising new treatment strategy for B cell malignancies — one using genetically engineered T cells. Of the eight men who received infusions of autologous T cells that were transduced with gamma-retroviruses encoding an anti-CD19 chimeric-antigen receptor, six experienced remissions. However, the researchers note that because the patients received chemotherapy prior to the T cell infusions, the contribution of CAR-transduced T cells to the remissions is unclear.
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Blood test predicts effectiveness of antidepressants
Laboratory Equipment
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Loyola University Medical Center researchers report what could become the first reliable method to predict whether an antidepressant will work on a depressed patient. A Loyola study found that among depressed patients who had higher than normal blood levels of protein vascular endothelial growth factor, more than 85 percent experienced partial or complete relief from depression after taking escitalopram. To compare, fewer than 10 percent of depressed patients who had low levels of VEGF responded to the drug.
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Scientists develop vaccine that successfully attacks
breast cancer in mice
Bioscience Technology
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Researchers at Mayo Clinic in Arizona and the University of Georgia have developed a vaccine that dramatically reduces tumors in a mouse model that mimics 90 percent of human breast and pancreatic cancer cases — including those that are resistant to common treatments. The vaccine, described in the journal Proceedings of the National Academy of Sciences, reveals a promising new strategy for treating cancers that share the same distinct carbohydrate signature, including ovarian and colorectal cancers.
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Cancer risk elevated in myotonic muscular dystrophy
Medscape Medical News
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Patients with myotonic muscular dystrophy are at increased risk of developing cancer, particularly of the brain, colon, ovary, and endometrium, a new study suggests. "It is important that clinicians evaluate new clinical symptoms in their myotonic dystrophy patients with the possibility of cancer in mind," Mark H. Greene, M.D., chief of the Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md.
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Testosterone replacement improves male metabolic syndrome
Medscape Medical News
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Testosterone replacement to normal levels in middle-aged and elderly hypogonadal men significantly improved all components of the metabolic syndrome at 24 months, according to research presented at the International Diabetes Federation World Diabetes Congress 2011. Positive effects were maintained for at least 60 months, reported Farid Saad, Ph.D., from Bayer Schering Pharma in Berlin, Germany, which sponsored the prospective observational study.
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Stem cell and gene therapy for sickle cell and other genetic diseases
University of California, San Francisco
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A cure for sickle cell anemia and other life-threatening genetic disorders that arise in the blood is the goal of a new $6.7-million, five-year research project headed by University of California, San Francisco scientist Y. W. Kan, a pioneer of modern genetics and the diagnosis of genetic diseases before birth. The preclinical research is funded through a competitively awarded grant from the National Institutes of Health.
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STA Coag ConneXion is an easy to use, Windows 7 based user interface that offers comprehensive QC management, remote QC capability and standardized result reporting with the use of expert rules for auto validation. For more information on STA Coag ConnneXion, visit www.stago-us.com.
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'Rule of 7s' shows accuracy in lyme meningitis prediction
Medscape Medical News
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The clinical prediction tool known as the "Rule of 7s" is reliable in identifying children with cerebrospinal fluid (CSF) pleocytosis who are at a low risk for Lyme meningitis, according to a study published online Dec. 19 in Pediatrics. Although clinical prediction tools can be useful in identifying children with CSF pleocytosis who are at a low risk for bacterial meningitis, the predictors do not rule out the potential for Lyme meningitis, which can take several days to diagnose with serology.
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Bone marrow transplant best for boosting blood cells
New Scientist
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Bone marrow transplants may beat stem-cell injections as a way of increasing the production of blood cells when tissue is from an unrelated donor. A potential problem of either treatment — used for diseases like sickle cell anemia — is graft-versus-host disease. This potentially fatal condition occurs when donated blood cells launch an immune attack on the host.
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Providing the accurate, dependable allergy, urinalysis and auto-immune results you require. Delivering the cost-effective test results you value. MORE |
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Tick disease up among elderly
Medical News Today
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A review of the Centers for Medicare & Medicaid Services administrative databases demonstrated an uptick of babesiosis cases over a three-year period, with regional cases increasing up to ten times greater than national rates, according to researchers.
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Grants to fund device for remote health diagnosis
The Associated Press via Seattle Post-Intelligencer
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Two of the biggest spenders on global health innovation are hoping that $38.5 million will be enough money to create a handheld device that doctors could use to diagnose patients far from medical labs. The battery-powered devices could be taken into remote areas to take samples from patients and provide analysis on various illnesses.
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CellaVision introduces CellAtlas®, the perfect way to learn the basics of hematology cell morphology. This App for the Apple iPhone and iPod Touch compliments our digital cell morphology portfolio, and is an educational tool to assist in the recognition and classification of blood cells, by utilizing mini-lectures and cell quizzes. More
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As a leader in fully automated immunoassay testing systems, Grifols USA Diagnostic Division’s premier product, the TRITURUS® ELISA System is an open, fully automated, multi-test and multi-batch immunoassay system. Grifols USA is a major distributor of quality IVD ELISA tests for Infectious Disease, Autoimmune Diseases and many other disease states. Grifols’ Diagnostic products take the complexity out of clinical diagnostic testing.
1-800-379-0957. diaginfo@grifols.com
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Cleveland Clinic Laboratories is a full-service, national reference lab dedicated to providing world class care. We have a dedicated staff of more than 1,300 employees, including board-certified subspecialty pathologists, PhDs, technologists, technicians, and support personnel. Cleveland Clinic Laboratories is proud to serve hospitals, outpatient facilities and physician offices worldwide. For more information, please visit clevelandcliniclabs.com.
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