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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Jan. 2, 2014


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SOCIETY NEWS


Win an iPad or AST Bucks with AST's Member-Get-A-Member Campaign
AST
If you find your AST membership a valuable professional resource, encourage your colleagues to join today with the AST's Member-Get-A-Member Campaign. For each new member you recruit, your name will be entered to win one of three prizes, and you'll receive recognition for your efforts at the 2014 World Transplant Congress (WTC), on the AST website and in the AST eNews. And, if your colleagues complete a membership application by Jan. 31, they'll get the member discounted registration rate for WTC. Strengthen the transplant community and help colleagues grow personally and professionally with an AST membership.
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Register for CEOT 2014 and we'll pay for your stay during the meeting
AST
The Cutting Edge of Transplantation (CEOT) promises to be an exciting and informative meeting where we will discuss the latest in graft survival through therapeutics, targets and technologies. Plan to join us Feb. 13-15 in Chandler, Ariz.

Register for CEOT by Friday, Jan. 10 at 11:59 p.m. PST and be entered to win two free nights at the Sheraton Wild Horse Pass during the 2014 CEOT meeting. Register now.

The winner will be announced on the CEOT website on Monday, Jan. 13.

*All current registrants will be automatically entered to win two free nights at the Sheraton Wild Horse Pass.

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AST members: Get more value out of your membership in 2014!
AST
Did you know that as an AST member, you are exempt from paying the $50 abstract submission fee for the World Transplant Congress? The deadline to submit your abstract is Jan. 10 – don't miss out!

AST members also enjoy reduced subscription fees to the American Journal of Transplantation, as well as significant discounts on registration to AST meetings, including CEOT and WTC. Members looking for additional networking and educational opportunities outside of our meetings may join any of our special interest Communities of Practice. The communities provide an array of benefits to members by promoting idea exchange and supporting the development of new resources that will advance niche areas of transplantation.

These are just some of the ways that an AST membership can help advance your career. Learn how to take full advantage of your membership here.Questions, comments and feedback may be sent to our member services team at info@myAST.org.

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PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


TRANSPLANT NEWS


Pediatric liver transplantation for urea cycle disorders and organic acidemias: United Network for Organ Sharing data for 2002-2012
Liver Transplantation (login requried)
Decision making concerning liver transplantation is unique for children with urea cycle disorders (UCDs) and organic acidemias (OAs) because of their immediate high priority on the waiting list, which is not related to the severity of their disease. There are limited national outcome data on which recommendations about liver transplantation for UCDs or OAs can be based. This study was a retrospective analysis of United Network for Organ Sharing data for liver recipients who underwent transplantation at an age  less than 18 years in 2002-2012. Repeat transplants were excluded. Among the pediatric liver transplants, 5.4 percent were liver-only for UCDs/OAs.
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Trajectories of perceived benefits in living kidney donors: Association with donor characteristics and recipient outcomes
Transplantation (login required)
While improved health of the recipient may serve as a primary motivating factor, living kidney donors also may expect to accrue some personal benefit following donation. This study sought to identify trajectories of perceived benefit over the first two years after donation.
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Automated image analysis method for detecting and quantifying macrovesicular steatosis in hematoxylin and eosin-stained histology images of human livers
Liver Transplantation (login required)
Large-droplet macrovesicular steatosis (ld-MaS) in more than 30 percent of liver graft hepatocytes is a major risk factor for liver transplantation. An accurate assessment of the ld-MaS percentage is crucial for determining liver graft transplantability, which is currently based on pathologists' evaluations of hematoxylin and eosin (H&E)–stained liver histology specimens, with the predominant criteria being the relative size of the lipid droplets (LDs) and their propensity to displace a hepatocyte's nucleus to the cell periphery. Automated image analysis systems aimed at objectively and reproducibly quantifying ld-MaS do not accurately differentiate large LDs from small-droplet macrovesicular steatosis and do not take into account LD-mediated nuclear displacement; this leads to a poor correlation with pathologists' assessments.
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Risk factors for neurological complications and their correlation with survival following pediatric liver transplantation
Pediatric Transplantation (login required)
Despite the improved outcomes of liver transplantation (LT), post-operative neurological complications (NC) remain a significant cause of morbidity and mortality. The aim of this study was to identify the incidence of and risk factors for NCs in children who underwent LT. The medical records of pediatric patients who underwent LT at Asan Medical Center Children's Hospital between January 1994 and December 2010 were retrospectively analyzed.
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.
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Rapid, efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers
NCBI
Human pluripotent stem cells (hPSCs) can generate a diversity of cell types, but few methods have been developed to derive cells of the kidney lineage. Here, authors report a highly efficient system for differentiating human embryonic stem cells and induced pluripotent stem cells (referred to collectively as hPSCs) into cells expressing markers of the intermediate mesoderm that subsequently form tubule-like structures.
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PRODUCT SHOWCASE
 
Astellas is entering its 20th year focusing on transplant immunology. Today we remain steadfast in our commitment to advancing the field. Tomorrow we will seek new possibilities to help improve the transplant experience. Together. Please visit astellas.us
 


Racial and socioeconomic disparities in pediatric and young adult liver transplant outcomes
Liver Transplantation (login required)
Racial and socioeconomic disparities exist in liver transplantation (LT) outcomes among adults, but little research exists for pediatric LT populations. In this study, authors examined racial differences in graft survival and mortality within a retrospective cohort of pediatric and young adult LT recipients at a large children's transplant center in the Southeast between 1998 and 2011. The association between race/ethnicity and rates of graft failure and mortality was examined with Cox proportional hazards models that were adjusted for demographic and clinical factors as well as individual-level and census tract–level socioeconomic status (SES).
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Prerecovery liver biopsy in the brain-dead donor: A case-control study of logistics, safety, precision and utility
Liver Transplantation (login required)
Prerecovery liver biopsy (PLB) can potentially to decrease futile recovery and increase utilization of marginal brain-dead donor (BDD) livers. A case-control study was conducted to examine the logistics, safety, histological precision and liver utilization associated with PLB in BDDs. Twenty-three cases between January 2008 and January 2013 were compared to two groups: 48 sequential and 69 clinically matched controls.
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Effects of preexisting autoimmunity on heart graft prolongation after donor-specific transfusion and anti-CD154
Transplantation (login required)
Alloreactive memory T cells prevent costimulatory blockade-induced heart graft survival in mice, but whether and how preexisting autoreactive T cells affect solid-organ transplants under these conditions is unknown.
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Colby Horton, Vice President of Publishing, 469.420.2601
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Courtney Hodges, Content Editor, 972.402.2604   
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