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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Jan. 17, 2013

 



5-year outcomes in living donor kidney transplants with a positive crossmatch
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Renal transplant candidates with high levels of donor-specific anti-HLA antibodies have low transplantation rates and high mortality rates on dialysis. Using desensitization protocols, good short-term outcomes are possible in "positive crossmatch kidney transplants (+XMKTx)," but long-term outcome data are lacking. The aim of the current study was to determine actual 5-year graft outcomes of +XMKTx. More

 SOCIETY NEWS


CEOT: Early registration discounts end soon
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Registration rates for the first annual Cutting Edge of Transplantation (CEOT) meeting increase after January 24; be sure to register soon! Join us Feb. 14-16 in Scottsdale, Arizona, to discuss the topics surrounding B cells and antibodies. With more than 30 talks from experts in the field of transplantation, CEOT promises to be an exciting and informative event.

Live and on-demand webinars free for AST members
AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article
AST offers two distinct webinar series for convenient online education catering to a wide audience; both are free to members and available for a fee to non-members. Visit a-s-t.org/T3 for the Timely Topics in Transplantation on-demand webinar series, and a-s-t.org/business for the live monthly Business of Transplantation webinar series (presented by the AST Transplant Administrators COP).

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Antibody mediated rejection in liver transplantation meeting March 2013 in Dallas
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Antibody mediated rejection is a well known and feared entity in all solid organ transplants – except the liver. Previous studies and literature regarding liver allografts have been inconsistent, and mounting evidence has shown the pathologic potential of DSA in liver and SLKT recipients. The goal of this conference is to bring about a meeting of the minds to define AMR in liver transplantation and forge a path for future research in this burgeoning area of research. Program information is available at www.DallasAMR.com. To register visit https://www.regonline.com/DallasAMR.

 TRANSPLANT NEWS


The rise of Clostridium difficile infection in lung transplant recipients in the modern era
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Clostridium difficile infection (CDI) rates have been rising in recent years. We aimed to characterize CDI in lung transplant recipients in the modern era and hypothesized that CDI would increase the mortality risk. DI rates in lung transplant recipients are high in the modern era. No risk factors for CDI were identified. More

Efficacy of the retreatment of hepatitis C virus infections after liver transplantation: Role of an aggressive approach
Liver Transplantation    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A sustained virological response (SVR) is achieved by 30 percent of naive liver transplantation (LT) recipients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV). Almost no data are available about retreatment. The aim a recent study was to assess the efficacy, tolerability and SVR predictors of retreatment. More


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Genetic testing can be a cost-effective way to increase the number of living related donor transplants. Mutational analysis may help direct long-term treatment plans, including pre-operative screening of potential kidney transplant recipients and living related donors.
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Inactivation of enveloped and non-enveloped viruses in the process of chemical treatment and gamma irradiation of bovine-derived grafting materials
Xenotransplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Xenografts, unlike other grafting products, cannot be commercialized unless they conform to stringent safety regulations. Particularly with bovine-derived materials, it is essential to remove viruses and inactivate infectious factors because of the possibility that raw materials are imbrued with infectious viruses. The removal of the characteristics of infectious viruses from the bovine bone grafting materials need to be proved and inactivation process should satisfy the management provision of the Food and Drug Administration (FDA). To date, while most virus inactivation studies were performed in human allograft tissues, there have been almost no studies on bovine bone. More

Study: Conversion to enteric-coated mycophenolate sodium from mycophenolate mofetil in stable renal transplant patients
Nephrology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Mycophenolate mofetil has proven efficacy in the prophylaxis of acute rejection in solid organ transplantation; however, gastrointestinal intolerance can risk this efficacy because of associated dose adjustments and discontinued treatment. Enteric-coated mycophenolate sodium has demonstrated improved gastrointestinal tolerability, but the data in Asian subjects are scarce. This study demonstrated that enteric-coated mycophenolate sodium is a safe and effective alternative to mycophenolate mofetil in Asian kidney transplant recipients. More



Leptin modulates allograft survival by favoring a Th2 and a regulatory immune profile
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Leptin, an adipose-secreted hormone, links metabolism and immunity. In a recent study, researchers sought to determine whether leptin affects the alloimmune response. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection. More

Travel and transplantation: Travel-related diseases in transplant recipients
Current Opinion in Organ Transplantation    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Travel-related diseases may be seen in transplant recipients after travel, after transplant tourism, and via transmission from blood and organ donors, augmented by recent increases in travel, migration, and globalization. Such infections include tuberculosis, Plasmodium (malaria), Babesia, Trypanosoma cruzi (Chagas disease), Strongyloides, Coccidioides, Histoplasma, Leishmania, Brucella, HTLV, dengue, among numerous others. More


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Cord blood t cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer Epstein-Barr virus specificity
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Adoptive T cell therapy can be effective for Epstein–Barr virus (EBV)-associated posttransplant lymphoproliferative disease and melanoma. Transducing high-affinity TCR genes into T lymphocytes is an emerging method to improve potency and specificity of tumor-specific T cells. However, both methods necessitate in vitro lymphocyte proliferation, generating highly differentiated effector cells that display reduced survival and antitumor efficacy postinfusion. More

Strategic breakthrough in adult ABO-incompatible living donor liver transplantation: Preliminary results of consecutive seven cases
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
ABO-incompatibility is a major obstacle to expanding exiguous donor pools in adult liver transplantation, especially in countries where grafts from deceased donors are uncommon. A recent report documents preliminary results of ABO-incompatible (ABO-I) adult living donor liver transplantation (LDLT) using a new, simple protocol. More
 



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