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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Jan. 17, 2014


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The equitable allocation of deceased donor lungs for transplant in children in the United States
American Journal of Transplantation (login required)
On June 5, a U.S. Federal Court ordered a temporary restraining order to allow two children within the court's jurisdiction to be registered on the adolescent lung transplant waiting list. On June 10, the Organ Procurement and Transplantation Network's Executive Committee altered lung allocation policy to offer candidates aged younger than 12 years greater access to adult lungs at the discretion of the national Lung Review Board. The Scientific Registry of Transplant Recipients reviewed trends over time in deceased donor lung transplant waitlist mortality and transplant rates, comparing children and adults.

Related article:
Pediatric lung allocation: the rest of the story (American Journal of Transplantation)

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SOCIETY NEWS


New kidney allocation policy — important AST webinar Jan. 21 — pre-register today
AST
On Tuesday, Jan. 21 at 2 p.m. ET, join Dr. John Friedewald, Past Chair of the OPTN/UNOS Kidney Committee, for a live summary and Q&A session on the new OPTN/UNOS policy on kidney allocation. Learn how to address implementation in your own transplant program, and find out what this will mean for patients currently on the waiting list and those currently being evaluated. This webinar is free to AST members and only $25 for non-members, register at www.myAST.org/T3.
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Register for CEOT and get one registration half-off for a limited time
AST
Register for the Cutting Edge of Transplantation (CEOT) in Chandler, Ariz., to secure your spot at this intimate meeting that will focus on long-term graft survival, and receive half off a second registration to CEOT. Book your hotel by Jan. 24 to get the AST special discounted rate.

This activity is jointly sponsored by Global Education Group and the American Society of Transplantation. Continuing education credit will be offered for physicians, nurses, pharmacists and transplant coordinators. Click here for full credit details. For information about accreditation of this program, please contact Global at 303-395-1782 or inquire@globaleducationgroup.com.

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PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


Get ready for WTC registration
AST
Do you plan to attend the 2014 World Transplant Congress (WTC) in San Francisco? AST members must pay their dues by April 1 to receive the discounted member registration rate! AST full, doctoral members receive 50 percent off the non-member registration rate. Not an AST member yet? Submit your application for membership today to take advantage of these savings. Pay it forward and help your colleagues save by referring them to join the AST today!
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Webinar for Fellows on Pathology: Liver, Kidney, Heart - Feb. 21
AST
Mark your calendar for Friday, Feb. 21 for a free webinar discussing cases where although pathology suggested rejection, there was an alternate diagnosis. The Fellows Live Webinar Series is designed for fellows in transplantation but is available to anyone free of charge. Click here to register for future webinars.
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Become an AST Corporate Affiliate
AST
The AST Corporate Affiliates Program provides an exciting opportunity for companies to support the work of the AST and receive tangible benefits throughout the year.

Benefits of participation include increased visibility, enhanced engagement opportunities, access to new marketing tools and up-to-date communication about the latest research and advocacy efforts in the field of transplantation. In addition to these benefits, companies participating in this program are invited to meet annually with senior AST leadership to engage in strategic discussions about key issues impacting the field of transplantation.

For additional information, please visit us at www.myAST.org/CAP, or contact Liz Piegzik, Associate Meeting Manager, at lpiegzik@myAST.org.

AST thanks the following companies for their participation in the 2014 Corporate Affiliates Program:
Genentech, a member of the Roche Group
Novartis Pharmaceuticals
Roche Diagnostics Corporation
Veloxis Pharmaceuticals

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TRANSPLANT NEWS


West Nile Virus infection in kidney and pancreas transplant recipients in the Dallas-Fort Worth Metroplex during the 2012 Texas epidemic
Transplantation (login required)
In 2012, the United States experienced one of its worst West Nile virus epidemics, reporting 5,387 human cases and final death toll of 243. Texas was at the epicenter of the outbreak, with 1,875 reported cases and 89 deaths that year. The Texas outbreak centered mainly in the Dallas-Fort Worth area where 30 deaths were reported. Authors report three cases of severe WNV infection complicated by meningoencephalitis in the organ transplant population.
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Patients' expectations and experiences of rehabilitation following lung transplantation
Clinical Transplantation (login required)
Exercise rehabilitation is a key element of care following lung transplantation; however, little is known about the patients' experience of rehabilitation, or whether it meets the needs of this complex patient group. This qualitative study explored patients' expectations of a supervised exercise rehabilitation program following lung transplantation.
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Gastrointestinal bleeding and subsequent risk of thromboembolic events during support with a left ventricular assist device
The Journal of Heart and Lung Transplantation (login required)
Modern left ventricular assist devices require anti-coagulation with warfarin and anti-platelet therapy to prevent thromboembolic complications in patients. Gastrointestinal bleeding is a significant adverse event in these patients and treatment typically requires reduction or elimination of AC or anti-platelet therapy. It is not known whether alterations in AC to treat GI bleeding influence subsequent risk of thromboembolic events during LVAD support.
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Interagency registry for mechanically assisted circulatory support analysis of pump thrombosis in the HeartMate II left ventricular assist device
The Journal of Heart and Lung Transplantation (login required)
Pump thrombosis remains an uncommon but potentially catastrophic complication of durable continuous-flow left ventricular assist devices (LVAD). A perceived increase in the incidence of pump thrombosis in the HeartMate II (HMII) LVAD by clinicians prompted this analysis of the Interagency Registry for Mechanically Assisted Circulatory Support database.
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.
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Innate immune cells in transplantation
Current Opinion in Organ Transplantation (login required)
This review examines the recent literature on the role of innate cells in immunity to transplanted tissue. It specifically addresses the impact of monocytes/macrophages, neutrophils, natural killer cells and platelets. Current research indicates that innate immunity plays a dual role in response to transplanted tissue with the ability to either facilitate rejection or promote tolerance. Intriguingly, some of these cells are even capable of reacting to allogeneic cells, a feature usually only attributed to cells of the adaptive immune system.
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Serum iron parameters in the early post-transplant period and infection risk in kidney transplant recipients
Transplant Infectious Disease (login required)
The impact of iron metabolism on the risk of infectious complications has been demonstrated in various immunosuppressed populations. However, no previous studies have assessed this potential association in kidney transplant recipients.
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PRODUCT SHOWCASE
 
Astellas is entering its 20th year focusing on transplant immunology. Today we remain steadfast in our commitment to advancing the field. Tomorrow we will seek new possibilities to help improve the transplant experience. Together. Please visit astellas.us
 


Treatment of chronic hepatitis C virus infection: Some remaining obstacles in the United States
Liver International (login required)
Hepatitis C infection is an important problem in inner city neighborhoods, which suffer from multiple health disparities. Important factors in this population include alcoholism and substance abuse, mental illness and homelessness, which may be combined with mistrust, poor health literacy, limited access to healthcare and outright discrimination. Systemic barriers to effective care include a lack of capacity to provide comprehensive care, insufficient insurance coverage, poor coordination among caregivers and between caregivers and hospitals, as well as third party payers. These barriers affect real world treatment effectiveness as opposed to treatment efficacy, the latter reflecting the world of clinical trials.
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Living donor liver transplantation for obese patients: Challenges and outcomes
Liver Transplantation (login required)
Living donor liver transplantation (LDLT) is an accepted option for end-stage liver disease, particularly in countries in which there are organ shortages. However, little is known about LDLT for obese patients. In this study, authors sought to determine the effects of obesity on pretransplant living donor selection for obese recipients and their outcomes.
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Lab notes: A new way to mend a broken heart
MedPage Today
A new adhesive that promises to work well in wet places may be just what heart surgeons have been looking for. Current surgical adhesives are toxic, have limited strength and don't work well in wet places, such as the heart. Inspired by insects, slugs, and worms, researchers led by Jeffrey Karp, Ph.D., of Brigham and Women's Hospital in Boston may have overcome those limitations.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Steroid avoidance in pediatric heart transplantation results in excellent graft survival (Transplantation)
Human microbiota characterization in the course of renal transplantation (American Journal of Transplantation)
Heart and combined heart-kidney transplantation in patients with concomitant renal insufficiency and end-stage heart failure (American Journal of Transplantation)
Pulsatile perfusion reduces risk of delayed graft function in deceased donor kidney transplants, irrespective of donor type, cold ischemic time (Transplantation)
The extent and predictors of waiting time geographic disparity in kidney transplantation in the United States (Transplantation)

Don't be left behind. Click here to see what else you missed.


Roles of toll-like receptors in transplantation
Current Opinion in Organ Transplantation (login required)
Beyond their crucial role in host defense against invading pathogens, Toll-like receptors (TLRs) are now known to be key mediators of the 'sterile' innate immune response triggered by tissue injury. Here, authors review recent evidence examining the role of TLRs in determining the fate of the transplanted organ.
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Colby Horton, Vice President of Publishing, 469.420.2601
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