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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Jan. 24, 2013


Treatment of steroid-resistant acute renal allograft rejection with alemtuzumab
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Steroid-resistant renal allograft rejections are commonly treated with rabbit antithymocyte globulin (RATG), but alemtuzumab could be an effective, safe and more convenient alternative. Adult patients with steroid-resistant renal allograft rejection treated with alemtuzumab (15–30 mg s.c. on two subsequent days) from 2008 to 2012 were compared to patients treated with RATG. More


CEOT: Last chance to save on registration
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Early registration rates for the Cutting Edge of Transplantation (CEOT) meeting, including the buy one registration, get one half off deal, end today. To take advantage of these discounts, register for CEOT today and book your hotel stay. The first annual CEOT meeting is Feb. 14-16 in Scottsdale, Ariz. Join the experts to tackle topics surrounding B cells and antibodies. View the program.

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2013 ITNS Transplant Nurses Contest
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The International Transplant Nurses Society (ITNS) has launched a contest for transplant patients to write about how a transplant nurse has made a difference in their lives. Transplant professionals are encouraged to spread the word and print the contest brochure for display at their hospital. For more information, click here.


COP executive committee call for nominations
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Nominations are now being taken for executive committee open positions in 10 Communities of Practice (COPs). The deadline to submit nominations is Feb. 22. To nominate yourself or a fellow colleague, you (the nominator) and the nominee must both be a member of that specific COP. Nominees must be an AST member in good standing. If you need to verify your or the nominee's COP membership, please feel free to contact Jason Polinsky at with your membership verification request. To submit a nomination, simply follow the links to forms for the co-chair positions and committee member-at-large positions.

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Declining liver utilization for transplantation in the United States and the impact of donation after cardiac death
Liver Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Worsening donor liver quality resulting in decreased organ utilization may be contributing to the recent decline in liver transplants nationally. In recent study, researchers sought to examine trends in donor liver utilization and the relationship between donor characteristics and nonuse. The United Network for Organ Sharing database was used to review all deceased adult organ donors in the United States from whom at least one solid organ was transplanted into a recipient. More

Serious acute kidney injury is on the rise
Renal & Urology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The incidence of acute kidney injury requiring dialysis is now higher than the incidence of end-stage renal disease requiring dialysis or transplant, discovered a team led by Dr. Chi-yuan Hsu, Nephrology Division Chief at the University of California-San Francisco (UCSF), and UCSF nephrology fellow Dr. Raymond Hsu. More

Use of immune function test in monitoring immunosuppression in liver transplant recipients
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Immune function test (Immuknow™) is a measure of cell-mediated immunity based on peripheral CD4+ T cell adenosine triphosphate activity (desired range, 225–525 ng/mL). A recent study evaluated the role of immune function test in monitoring and adjustment of immunosuppression in orthotopic liver transplant recipients. More

Intense diuresis plan promising in heart failure
MedPage Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A diuretic protocol designed to allow rapid real time assessment and adjustment of treatment for acute heart failure patients showed gains, but also potential losses, according to an observational study. Patients with acute decompensated heart failure on the diuretic protocol were 54 percent less likely to be readmitted to the hospital compared with the usual care group, according to Dr. Jeffrey H. Barsuk, MS, and colleagues from Northwestern University Feinberg School of Medicine in Chicago. More

Immunological monitoring after pancreas transplantation
Current Opinion in Organ Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
After switching from bladder to enteric drainage, pancreas graft monitoring, particularly after solitary transplantation, has become an important issue. The aim of a recent study was to systematically review the relevant literature with regard to various biomarkers, imaging techniques and pathologic evaluation of allograft tissue. More

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Study: Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine
American Journal of Transplantation    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Polyomavirus BK (BKV)-associated nephropathy causes premature kidney transplant (KT) failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk factors are controversial. In a recent study, 682 KT patients receiving basiliximab, mycophenolic acid (MPA), corticosteroids were randomized 1:1 to cyclosporine (CsA) or tacrolimus (Tac). The data suggest a dynamic risk factor evolution of BKV viremia consisting of higher corticosteroids until month 3, Tac-MPA compared to CsA-MPA at month 6 and Tac-MPA, older age, male gender at month 12 posttransplant. More

Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients
Transplant International (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Protocols for recipient desensitization may allow for successful kidney transplantation across major immunological barriers. Desensitized recipients, however, still face a considerable risk of antibody-mediated rejection (AMR), which underscores the need for risk stratification tools to individually tailor treatment. Here, researchers investigated whether solid phase detection of complement-fixing donor-specific antibodies has the potential to improve AMR prediction in high-risk transplants. More

Transumbilical portal venous catheterization: A useful adjunct in left lobe living donor liver transplantation
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
To improve the processes used for perfusion of the explanted graft and measuring the portal venous pressure in adult living donor transplantation, researchers performed transumbilical portal venous catheterization to reopen the umbilical vein and insert the catheter for seven adult patients undergoing left lobe LDLT. More

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